Systemic Drug Therapy | Clinical Pharmacy & Therapeutics | GPAT Mock Test

1. Which of the following drugs irreversibly inhibits the H+/K+ ATPase pump in gastric parietal cells?

2. The standard first-line triple therapy for Helicobacter pylori eradication includes a proton pump inhibitor, clarithromycin, and which other drug?

3. Mesalazine (5-aminosalicylic acid) is a primary treatment for which of the following conditions?

4. Ondansetron is a highly effective antiemetic used for chemotherapy-induced nausea and vomiting. Its mechanism of action involves antagonism of:

5. Which of the following is an osmotic laxative used to treat constipation?

6. Sofosbuvir is a direct-acting antiviral agent used in the treatment of Hepatitis C. It works by inhibiting:

7. Which of the following drugs is a non-selective beta-blocker used to reduce portal hypertension in patients with cirrhosis?

8. Hepatic encephalopathy is managed by reducing ammonia levels in the blood. Which drug achieves this by acidifying the colon and promoting ammonia excretion?

9. The specific antidote for paracetamol (acetaminophen) induced hepatotoxicity is:

10. Which class of diuretics is most effective in patients with advanced Chronic Kidney Disease (CKD) (GFR < 30 mL/min)?

11. A major dose-limiting side effect associated with long-term use of aminoglycoside antibiotics like gentamicin is:

12. Which of the following is used for the emergency management of severe hyperkalemia in a patient with renal failure?

13. Anemia in Chronic Kidney Disease is primarily treated with erythropoiesis-stimulating agents (ESAs) like epoetin alfa, along with supplementation of:

14. A common and persistent side effect of ACE inhibitors, such as lisinopril, is:

15. Statins (e.g., Atorvastatin) lower cholesterol levels primarily by inhibiting which enzyme?

16. Which of the following is the drug of choice for providing rapid relief from an acute attack of angina pectoris?

17. Which of the following beta-blockers is cardioselective and therefore safer to use in patients with asthma?

18. Warfarin exerts its anticoagulant effect by inhibiting the synthesis of vitamin K-dependent clotting factors. Which enzyme does it primarily target?

19. Which drug class has shown significant mortality benefit in patients with heart failure with reduced ejection fraction (HFrEF)?

20. Aspirin’s antiplatelet effect is due to the irreversible inhibition of:

21. Which of the following is a short-acting beta-2 agonist (SABA) used as a “reliever” medication for acute asthma symptoms?

22. The first-line controller therapy for persistent asthma in most patients is:

23. Montelukast is used in the management of asthma and allergic rhinitis. It acts by blocking the action of:

24. Tiotropium is a long-acting anticholinergic agent used for the maintenance treatment of COPD. Its primary mechanism is:

25. Which of the following is a second-generation antihistamine used for allergic rhinitis, known for its non-sedating properties?