Steroids & Anticancer Agents | Medicinal Chemistry | GPAT Mock Test

1. The fundamental ring structure common to all steroids is the:

2. Which substitution on the cortisol structure significantly increases both glucocorticoid and mineralocorticoid activity?

3. The anti-inflammatory action of glucocorticoids is primarily mediated by the inhibition of which enzyme?

4. Aldosterone’s primary function is to regulate the reabsorption of which ion in the kidneys?

5. Which of the following is a Selective Estrogen Receptor Modulator (SERM) used in the treatment of breast cancer?

6. The “minipill” type of oral contraceptive contains:

7. The 17α-alkylation of testosterone is a common structural modification primarily intended to:

8. Methotrexate exerts its anticancer effect by inhibiting which enzyme?

9. Cyclophosphamide is a prodrug that requires metabolic activation by which enzyme system?

10. Vincristine and Vinblastine, derived from the periwinkle plant, disrupt cell division by targeting:

11. Doxorubicin is known to cause cardiotoxicity as a major side effect. This is believed to be caused by:

12. Aromatase is the key enzyme responsible for the conversion of:

13. Imatinib (Gleevec) is a tyrosine kinase inhibitor specifically designed to target the protein product of which chromosomal abnormality?

14. The presence of a C1-C2 double bond in the A ring of a corticosteroid (e.g., in Prednisolone vs. Hydrocortisone) primarily results in:

15. Cisplatin and its analogs exert their cytotoxic effect by:

16. 5-Fluorouracil (5-FU) is a pyrimidine analog that primarily inhibits which enzyme?

17. A common adverse effect associated with the long-term misuse of anabolic steroids in males is:

18. Which of the following corticosteroids has the highest anti-inflammatory potency?

19. Paclitaxel (Taxol) functions as an anticancer agent by:

20. Spironolactone is a competitive antagonist at which receptor?

21. Trastuzumab (Herceptin) is a monoclonal antibody used to treat breast cancers that overexpress which receptor?

22. The primary mechanism of action of combination oral contraceptives (estrogen + progestin) is:

23. Leuprolide, used in the treatment of prostate cancer, acts as a(n):

24. The immediate precursor for the biosynthesis of all steroid hormones in the adrenal cortex is:

25. Gossypol, a compound investigated for male contraception, acts by: