Quinapril hydrochloride MCQs With Answer

Quinapril hydrochloride MCQs With Answer is a focused study resource tailored for B.Pharm students covering quinapril’s pharmacology, mechanism, clinical uses, pharmacokinetics, adverse effects, and drug interactions. These questions emphasize core concepts like ACE inhibition, prodrug activation to quinaprilat, therapeutic indications (hypertension, heart failure), safety issues (pregnancy contraindication, hyperkalemia, angioedema), and monitoring parameters (renal function, electrolytes). The set reinforces formulation, dosing considerations, and common pharmaceutical incompatibilities to prepare students for exams and clinical practice. Each MCQ is designed to deepen understanding and application of drug knowledge in pharmacy. Now let’s test your knowledge with 30 MCQs on this topic.

Q1. Which mechanism best describes how quinapril lowers blood pressure?

• Beta-adrenergic receptor blockade
• Calcium channel blockade
• Angiotensin-converting enzyme (ACE) inhibition
• Direct vasodilator action on smooth muscle

Correct Answer: Angiotensin-converting enzyme (ACE) inhibition

Q2. Quinapril is best described pharmacologically as:

• An active ACE inhibitor given IV
• A prodrug converted to an active metabolite
• A direct renin inhibitor
• A potassium-sparing diuretic

Correct Answer: A prodrug converted to an active metabolite

Q3. The active metabolite of quinapril responsible for ACE inhibition is:

• Quinidine
• Quinaprilat
• Quinazolide
• Quinoline

Correct Answer: Quinaprilat

Q4. Which clinical indication is NOT a primary use of quinapril?

• Hypertension
• Heart failure management
• Acute bacterial infection
• Reduction of diabetic nephropathy progression

Correct Answer: Acute bacterial infection

Q5. A major contraindication for quinapril therapy is:

• Controlled hypertension in adults
• Pregnancy
• Mild transient cough
• Hyperlipidemia

Correct Answer: Pregnancy

Q6. Which adverse effect is classically associated with ACE inhibitors including quinapril?

• Tinnitus
• Persistent dry cough
• Hyperglycemia
• Weight gain

Correct Answer: Persistent dry cough

Q7. Quinapril can cause hyperkalemia especially when combined with:

• Loop diuretics
• Thiazide diuretics
• Potassium-sparing diuretics or supplements
• Beta-blockers

Correct Answer: Potassium-sparing diuretics or supplements

Q8. Which laboratory parameters should be monitored after initiating quinapril?

• Liver enzymes and bilirubin only
• Complete blood count only
• Serum creatinine and potassium
• Fasting glucose and lipid profile only

Correct Answer: Serum creatinine and potassium

Q9. The conversion of quinapril to quinaprilat primarily occurs in:

• The gastrointestinal lumen by acids
• The liver via hepatic hydrolysis
• The lungs via pulmonary enzymes
• Renal tubular cells exclusively

Correct Answer: The liver via hepatic hydrolysis

Q10. Which drug interaction with quinapril may reduce its antihypertensive effect?

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Thiazide diuretics
• Calcium channel blockers
• Statins

Correct Answer: Nonsteroidal anti-inflammatory drugs (NSAIDs)

Q11. Quinapril hydrochloride as a salt form is used primarily to:

• Increase lipophilicity for CNS penetration
• Enhance water solubility and formulation stability
• Make the drug fluorescent for assays
• Convert it to an active metabolite

Correct Answer: Enhance water solubility and formulation stability

Q12. In patients with bilateral renal artery stenosis, ACE inhibitors like quinapril can cause:

• Marked improvement in GFR
• No change in renal function
• Acute renal failure due to reduced glomerular perfusion
• Hypokalemia and metabolic alkalosis

Correct Answer: Acute renal failure due to reduced glomerular perfusion

Q13. The antihypertensive effect of quinapril is primarily due to decreased formation of:

• Aldosterone only
• Bradykinin
• Angiotensin II
• Norepinephrine

Correct Answer: Angiotensin II

Q14. Which side effect is an emergency associated with ACE inhibitors requiring immediate discontinuation?

• Mild dizziness
• Angioedema with airway compromise
• Transient nausea
• Peripheral edema without respiratory symptoms

Correct Answer: Angioedema with airway compromise

Q15. A common starting oral dose range of quinapril for hypertension in adults is typically:

• 0.5–1 mg daily
• 10–20 mg daily
• 200–400 mg daily
• 1000 mg single dose

Correct Answer: 10–20 mg daily

Q16. Which of the following best describes quinapril’s elimination?

• Excreted unchanged in bile only
• Renal excretion of active metabolite and metabolites
• Eliminated exclusively by pulmonary exhalation
• Cleared entirely by enterohepatic recycling

Correct Answer: Renal excretion of active metabolite and metabolites

Q17. Combining quinapril with which class increases risk of symptomatic hypotension and renal dysfunction?

• Loop diuretics
• Antacids
• Topical corticosteroids
• Antihistamines

Correct Answer: Loop diuretics

Q18. The characteristic cough from ACE inhibitors is thought to be due to accumulation of:

• Prostaglandins
• Bradykinin and substance P
• Histamine
• Acetylcholine

Correct Answer: Bradykinin and substance P

Q19. For pharmaceutical handling, quinapril tablets should be stored:

• Frozen below 0°C
• At controlled room temperature away from moisture
• In direct sunlight for stability
• In open containers to air-dry

Correct Answer: At controlled room temperature away from moisture

Q20. In elderly patients, quinapril dosing often requires:

• No monitoring or dose adjustment ever
• Closer monitoring and possible lower initial doses
• Immediate high-dose therapy
• Switch to intravenous administration

Correct Answer: Closer monitoring and possible lower initial doses

Q21. Which monitoring finding indicates a likely adverse renal response to quinapril?

• Decreased serum creatinine
• Stable potassium and creatinine
• Rising serum creatinine and hyperkalemia
• Decreased blood urea nitrogen (BUN)

Correct Answer: Rising serum creatinine and hyperkalemia

Q22. Which statement about quinapril’s onset of action is correct?

• It acts instantly within seconds after oral dosing
• Antihypertensive effects develop over hours after oral absorption and activation
• It requires parenteral administration to work
• It only works after several months of therapy

Correct Answer: Antihypertensive effects develop over hours after oral absorption and activation

Q23. Which patient instruction is appropriate when starting quinapril?

• Stop monitoring blood pressure at home
• Avoid potassium supplements unless advised by a clinician
• Increase dietary potassium immediately
• Double the dose if blood pressure not controlled after one day

Correct Answer: Avoid potassium supplements unless advised by a clinician

Q24. Which biochemical change is expected with ACE inhibitor therapy like quinapril?

• Decrease in serum potassium
• Increase in angiotensin II levels
• Decrease in aldosterone leading to potassium retention
• Increase in renin activity due to feedback

Correct Answer: Increase in renin activity due to feedback

Q25. Overdose management of quinapril focuses primarily on:

• Gastric lavage only without supportive care
• Supportive care with IV fluids and vasopressors for hypotension
• Administering high-dose potassium
• Immediate dialysis as first-line in all cases

Correct Answer: Supportive care with IV fluids and vasopressors for hypotension

Q26. Which pharmacokinetic property describes quinapril?

• It is not absorbed orally
• It is orally bioavailable and converted to active quinaprilat
• It is only effective if given intramuscularly
• It is stored in adipose tissue long-term

Correct Answer: It is orally bioavailable and converted to active quinaprilat

Q27. Which condition increases the risk of angioedema with ACE inhibitors?

• Prior history of angioedema with ACE inhibitors
• Well-controlled asthma
• Hyperthyroidism
• Low dietary sodium alone

Correct Answer: Prior history of angioedema with ACE inhibitors

Q28. In pharmacy practice, counseling on missed doses of quinapril should advise:

• Double the next dose if one is missed
• Take the missed dose as soon as remembered unless close to the next dose
• Stop therapy permanently after one missed dose
• Take a triple dose next day

Correct Answer: Take the missed dose as soon as remembered unless close to the next dose

Q29. Which adjunctive therapy is commonly combined with quinapril for resistant hypertension?

• Potassium supplements
• Thiazide or loop diuretics
• High-dose NSAIDs
• ACE inhibitor at higher dose without monitoring

Correct Answer: Thiazide or loop diuretics

Q30. For formulation development, a key pharmaceutical consideration for quinapril hydrochloride is:

• Its photosensitivity requiring opaque packaging
• Its complete insolubility in all solvents
• Its inability to form salts
• Its gaseous state at room temperature

Correct Answer: Its photosensitivity requiring opaque packaging

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

Mail- Sachin@pharmacyfreak.com