Principles & Common Vaccines MCQ Quiz | Vaccines

Welcome to this comprehensive MCQ quiz on the Principles and Common Vaccines, designed specifically for MBBS students. This quiz will test your understanding of core immunological principles, vaccine types (live attenuated, inactivated, subunit, toxoid, mRNA), and their mechanisms. It also covers essential knowledge about common vaccines included in national immunization schedules, such as BCG, OPV, MMR, and Pentavalent vaccines. You will be challenged on topics like the cold chain, herd immunity, contraindications, and adverse events following immunization (AEFI). This is an excellent tool for self-assessment and revision. After completing the quiz, you can download all the questions along with their correct answers in a PDF format for your future reference. Good luck!

1. What is the primary determinant of the herd immunity threshold required to prevent an epidemic of an infectious disease?

2. Which of the following is a key characteristic of live attenuated vaccines?

3. What is the primary function of an adjuvant, such as aluminum salts, in a vaccine?

4. The BCG vaccine provides the most significant protection against which form of tuberculosis?

5. Which statement correctly differentiates Oral Polio Vaccine (OPV) from Inactivated Polio Vaccine (IPV)?

6. Tetanus and Diphtheria vaccines are examples of which type of vaccine?

7. The Hepatitis B vaccine is a classic example of which vaccine technology?

8. Which condition is an absolute contraindication for the administration of most live attenuated vaccines like MMR and Varicella?

9. What is the mechanism of action of mRNA vaccines (e.g., Pfizer-BioNTech, Moderna for COVID-19)?

10. The Rotavirus vaccine is administered via which route?

11. What is the standard temperature range for the “cold chain” for most refrigerated vaccines?

12. What does a Vaccine Vial Monitor (VVM) indicate?

13. Conjugate vaccines like PCV13 are specifically designed to be effective in infants under 2 years by:

14. Anaphylaxis following vaccination is classified as which type of Adverse Event Following Immunization (AEFI)?

15. The Human Papillomavirus (HPV) vaccine is primarily aimed at preventing which condition?

16. The administration of Rabies Immunoglobulin (RIG) after a suspected rabid animal bite provides what type of immunity?

17. What is the main advantage of the acellular pertussis (aP) component in DTaP vaccine compared to the whole-cell (wP) component in DTwP?

18. According to the National Immunization Schedule (India), when is the BCG vaccine typically administered?

19. The pentavalent vaccine used in many national programs protects against which five diseases?

20. Why is the influenza vaccine typically recommended annually?

21. Thimerosal, a mercury-containing compound, was historically used in multi-dose vaccine vials for what purpose?

22. The concept of a “reverse cold chain” is essential for which of the following activities in public health?

23. A major disadvantage of inactivated vaccines compared to live attenuated vaccines is:

24. The Varicella vaccine protects against which common childhood disease?

25. A single dose of the measles vaccine administered at or after 12 months of age provides what approximate level of protection?