Peptic Ulcer Disease MCQ Quiz | Stomach & Duodenum

Welcome to this specialized quiz on Peptic Ulcer Disease (PUD), designed for MBBS students. This assessment will test your understanding of the etiology, pathophysiology, clinical presentation, diagnosis, and management of gastric and duodenal ulcers. Covering key topics from H. pylori infection and NSAID-induced ulcers to complications like hemorrhage and perforation, these 25 multiple-choice questions are structured to reinforce your learning and prepare you for examinations. After submitting your answers, you’ll receive your score and see a detailed breakdown of the correct and incorrect responses. For your future reference and study, you can also download a PDF document containing all the questions along with their correct answers. Good luck!

1. What is the most common cause of Peptic Ulcer Disease (PUD) worldwide?

2. The primary mechanism by which NSAIDs cause peptic ulcers is:

3. A patient presents with epigastric pain that is typically relieved by eating. This clinical feature is most characteristic of:

4. What is the “gold standard” for diagnosing H. pylori infection?

5. Which artery is most commonly eroded by a bleeding posterior duodenal ulcer?

6. Proton Pump Inhibitors (PPIs) exert their effect by:

7. The most common complication of peptic ulcer disease is:

8. A patient with a perforated peptic ulcer is most likely to show which sign on an erect chest X-ray?

9. Zollinger-Ellison syndrome is characterized by a tumor that secretes which hormone?

10. Cushing’s ulcers are stress-induced ulcers associated with:

11. Which non-invasive test for H. pylori is recommended to confirm eradication after treatment?

12. The Forrest classification system is used to:

13. In the Johnson classification for gastric ulcers, a Type I ulcer is located at the:

14. Which of the following is NOT a component of the standard first-line triple therapy for H. pylori eradication?

15. What is the mechanism of action of Sucralfate in treating PUD?

16. A patient on long-term NSAID therapy develops an ulcer. The most appropriate prophylactic agent to prevent recurrence is:

17. Which of the following statements about duodenal ulcers is generally TRUE compared to gastric ulcers?

18. Gastric outlet obstruction secondary to PUD typically presents with:

19. Which endoscopic finding is most reassuring for a benign gastric ulcer?

20. What is a Curling’s ulcer?

21. A patient’s standard triple therapy for H. pylori fails. What is the most common component of the subsequent “quadruple therapy”?

22. The pain of a gastric ulcer is typically ________ by eating, whereas the pain of a duodenal ulcer is typically ________ by eating.

23. Which of the following lifestyle factors has the strongest association with PUD and delayed ulcer healing?

24. Penetration is a complication of PUD where the ulcer erodes into an adjacent organ. A posterior duodenal ulcer most commonly penetrates which organ?

25. A patient with PUD has alarm features including dysphagia, significant weight loss, and iron deficiency anemia. What is the most crucial next step in management?