Peptic Ulcer Disease MCQ Quiz | Stomach & Duodenum

1. What is the most common cause of Peptic Ulcer Disease (PUD) worldwide?

2. The primary mechanism by which NSAIDs cause peptic ulcers is:

3. A patient presents with epigastric pain that is typically relieved by eating. This clinical feature is most characteristic of:

4. What is the “gold standard” for diagnosing H. pylori infection?

5. Which artery is most commonly eroded by a bleeding posterior duodenal ulcer?

6. Proton Pump Inhibitors (PPIs) exert their effect by:

7. The most common complication of peptic ulcer disease is:

8. A patient with a perforated peptic ulcer is most likely to show which sign on an erect chest X-ray?

9. Zollinger-Ellison syndrome is characterized by a tumor that secretes which hormone?

10. Cushing’s ulcers are stress-induced ulcers associated with:

11. Which non-invasive test for H. pylori is recommended to confirm eradication after treatment?

12. The Forrest classification system is used to:

13. In the Johnson classification for gastric ulcers, a Type I ulcer is located at the:

14. Which of the following is NOT a component of the standard first-line triple therapy for H. pylori eradication?

15. What is the mechanism of action of Sucralfate in treating PUD?

16. A patient on long-term NSAID therapy develops an ulcer. The most appropriate prophylactic agent to prevent recurrence is:

17. Which of the following statements about duodenal ulcers is generally TRUE compared to gastric ulcers?

18. Gastric outlet obstruction secondary to PUD typically presents with:

19. Which endoscopic finding is most reassuring for a benign gastric ulcer?

20. What is a Curling’s ulcer?

21. A patient’s standard triple therapy for H. pylori fails. What is the most common component of the subsequent “quadruple therapy”?

22. The pain of a gastric ulcer is typically ________ by eating, whereas the pain of a duodenal ulcer is typically ________ by eating.

23. Which of the following lifestyle factors has the strongest association with PUD and delayed ulcer healing?

24. Penetration is a complication of PUD where the ulcer erodes into an adjacent organ. A posterior duodenal ulcer most commonly penetrates which organ?

25. A patient with PUD has alarm features including dysphagia, significant weight loss, and iron deficiency anemia. What is the most crucial next step in management?