Pancreatic Hormones (Insulin/Glucagon) MCQ Quiz | Endocrine Biochemistry

Welcome, MBBS students, to this specialized quiz on Pancreatic Hormones. This quiz is designed to test your understanding of the intricate biochemical pathways and clinical significance of insulin and glucagon. Covering 25 multiple-choice questions, it delves into topics such as hormone synthesis, receptor signaling, metabolic effects, and pathophysiological states like diabetes mellitus. This assessment is an excellent tool for self-evaluation and revision for your endocrine biochemistry module. After submitting your answers, you will receive your score and see a detailed breakdown of correct and incorrect responses. For your convenience, you can also download a PDF copy of all questions with their correct answers to aid in your future studies. Good luck!

1. Where is proinsulin cleaved into insulin and C-peptide?

2. What type of receptor is the insulin receptor?

3. Which glucose transporter is insulin-dependent and found primarily in adipose tissue and skeletal muscle?

4. Glucagon primarily acts on which organ to increase blood glucose levels?

5. What is the clinical significance of measuring C-peptide levels?

6. The two polypeptide chains of mature insulin are linked by:

7. Glucagon is derived from which precursor molecule?

8. Insulin promotes which of the following processes in adipocytes?

9. Which of the following is the most potent stimulus for glucagon secretion from pancreatic alpha cells?

10. Insulin stimulates glycogenesis by activating which enzyme?

11. Which gastrointestinal hormones enhance glucose-stimulated insulin secretion (incretin effect)?

12. The initial event triggering insulin release from pancreatic beta cells is the entry of glucose via which transporter?

13. Insulin administration can cause which electrolyte imbalance?

14. Glucagon promotes ketogenesis by inhibiting which enzyme in the liver?

15. The primary biochemical defect in Type 1 Diabetes Mellitus is:

16. In insulin resistance, there is a decreased cellular response to insulin, often associated with a post-receptor defect involving:

17. Insulin inhibits the activity of which enzyme, thereby reducing lipolysis?

18. Somatostatin, secreted by pancreatic delta cells, has what effect on insulin and glucagon?

19. The cellular effects of glucagon are primarily mediated through which second messenger system?

20. The primary sites for insulin degradation in the body are the:

21. Sulfonylurea drugs increase insulin secretion by acting on which channel in pancreatic beta cells?

22. Besides glucagon, which of the following is a major counter-regulatory hormone to insulin?

23. Which of the following best describes the overall metabolic effect of insulin?

24. During a prolonged fast, which hormone’s plasma concentration is expected to be significantly elevated?

25. A food with a high glycemic index typically causes a rapid and large increase in: