Myasthenia Gravis & NMJ Disorders MCQ Quiz | Neurology

Quiz Introduction

Welcome, future clinicians! This quiz is designed to test your understanding of Myasthenia Gravis and other Neuromuscular Junction (NMJ) disorders, a critical topic in Neurology for MBBS students. You will face 25 multiple-choice questions covering pathophysiology, clinical presentation, diagnosis, and management of conditions like Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome, and Botulism. This interactive quiz will help you consolidate your knowledge and prepare for your examinations. After submitting your answers, you will receive your score instantly, with a clear breakdown of correct and incorrect responses. For your revision, you can also download a PDF copy of all questions with their correct answers. Good luck, and may your synapses fire correctly!

1. The primary pathophysiological mechanism in Myasthenia Gravis involves antibodies directed against which of the following targets?

2. A 45-year-old male with a history of smoking presents with proximal muscle weakness that improves with repeated activity. He also complains of a dry mouth and constipation. Which associated malignancy is most commonly found with this condition?

3. The characteristic finding on repetitive nerve stimulation (RNS) in a patient with Myasthenia Gravis is:

4. Which of the following drugs is known to exacerbate symptoms in Myasthenia Gravis and should be used with caution?

5. The “ice pack test” is a simple bedside clinical test used to evaluate which specific sign in Myasthenia Gravis?

6. A patient with known Myasthenia Gravis on pyridostigmine presents to the emergency department with severe respiratory distress, muscle fasciculations, diarrhea, and excessive salivation. This clinical picture is most suggestive of:

7. The mechanism of action of botulinum toxin at the neuromuscular junction is:

8. Which of the following is the most sensitive diagnostic test for detecting impaired neuromuscular transmission, especially in ocular Myasthenia Gravis?

9. The first-line symptomatic treatment for most patients with Myasthenia Gravis is:

10. A clinical feature that helps distinguish Lambert-Eaton Myasthenic Syndrome (LEMS) from Myasthenia Gravis is:

11. What is the classic presentation of infantile botulism?

12. Thymectomy is a therapeutic option in Myasthenia Gravis, particularly for patients who are:

13. The drug 3,4-Diaminopyridine (Amifampridine) is specifically approved for the treatment of which NMJ disorder?

14. What is the primary mechanism of action of Pyridostigmine in treating Myasthenia Gravis?

15. A patient with Myasthenia Gravis who is negative for both AChR and MuSK antibodies is referred to as having which type of MG?

16. The characteristic pattern of paralysis in foodborne botulism is:

17. Which of the following is NOT a typical muscarinic side effect of acetylcholinesterase inhibitors like pyridostigmine?

18. Myasthenic crisis is a life-threatening complication characterized by:

19. In MuSK-positive Myasthenia Gravis, which clinical features are often more prominent compared to AChR-positive MG?

20. The underlying cause of transient neonatal myasthenia is:

21. Which organophosphate compound causes an irreversible inhibition of acetylcholinesterase, leading to a severe cholinergic syndrome?

22. Rapid, short-term improvement in severe Myasthenia Gravis or myasthenic crisis can be achieved with:

23. In contrast to LEMS, deep tendon reflexes in Myasthenia Gravis are typically:

24. Botulinum toxin cleaves which group of proteins to inhibit neurotransmitter release?

25. A patient with generalized myasthenia gravis is well-controlled on pyridostigmine and prednisone. A CT scan of the chest is ordered primarily to look for: