Metabolic & Other Bone Diseases MCQ Quiz | Rheumatology & Immunology

Welcome to the Metabolic & Other Bone Diseases quiz, specifically designed for MBBS students studying Rheumatology and Immunology. This quiz features 25 multiple-choice questions covering key topics such as Osteoporosis, Osteomalacia, Rickets, Paget’s disease, and disorders of parathyroid hormone. Each question is crafted to test your understanding of pathophysiology, clinical presentation, diagnosis, and management principles. This assessment will help you consolidate your knowledge and prepare for your examinations. After submitting your answers, you’ll receive your score and can review the correct responses. For your convenience, you can also download all the questions along with their correct answers in a PDF format for future reference and revision. Good luck!

1. According to WHO criteria, osteoporosis is defined by a bone mineral density (BMD) T-score of:

2. The first-line pharmacological treatment for most postmenopausal women with osteoporosis is:

3. Osteomalacia is primarily characterized by:

4. A classic radiographic finding in childhood rickets is:

5. What is the typical biochemical profile in vitamin D deficiency osteomalacia?

6. The hallmark of Paget’s disease of bone is:

7. The most characteristic laboratory finding in active Paget’s disease of bone is a markedly elevated:

8. A serious but rare complication of Paget’s disease is malignant transformation into:

9. “Brown tumors” seen on X-ray are classically associated with which condition?

10. The most common cause of primary hyperparathyroidism is:

11. Chronic glucocorticoid use contributes to osteoporosis primarily by:

12. What is the primary mechanism of action of bisphosphonates in treating osteoporosis?

13. Looser’s zones, or pseudofractures, are thin, transverse radiolucent lines in the cortex and are pathognomonic for:

14. Renal osteodystrophy is a complex bone disease that occurs in patients with chronic kidney disease (CKD), primarily due to:

15. The “salt and pepper” appearance of the skull on an X-ray is a characteristic finding in:

16. The FRAX (Fracture Risk Assessment Tool) score is used to estimate:

17. Deficiency of which vitamin is the most common cause of rickets and osteomalacia worldwide?

18. Trousseau’s sign of latent tetany (carpopedal spasm induced by ischemia) is a clinical indicator of:

19. Denosumab is a monoclonal antibody used to treat osteoporosis that works by inhibiting:

20. An elderly patient presents with bone pain, an enlarged skull, hearing loss, and a markedly elevated serum alkaline phosphatase. Calcium and phosphate levels are normal. The most likely diagnosis is:

21. Osteogenesis imperfecta, also known as brittle bone disease, is a genetic disorder caused by a defect in the synthesis of:

22. Which of the following is generally NOT considered a major risk factor for osteoporosis?

23. Teriparatide, a recombinant form of parathyroid hormone, is unique among osteoporosis treatments because it primarily:

24. The “rugger-jersey spine,” characterized by sclerotic bands at the top and bottom of vertebrae, is a radiographic sign associated with:

25. Scurvy leads to defective bone and connective tissue formation due to impaired: