Malignant Disorders | Clinical Pharmacy & Therapeutics | GPAT Mock Test

1. Imatinib is a targeted therapy highly effective in Chronic Myeloid Leukemia (CML) by selectively inhibiting which of the following?

2. The cumulative dose-limiting toxicity associated with the anthracycline antibiotic Doxorubicin is:

3. The primary mechanism of action for Cisplatin and other platinum-based compounds in treating solid tumors is:

4. Hemorrhagic cystitis is a characteristic and severe side effect caused by the accumulation of acrolein, a metabolite of which alkylating agent?

5. “Leucovorin rescue” is a critical intervention used to mitigate the toxicity of high-dose therapy with which antimetabolite?

6. While both are vinca alkaloids, Vincristine is known for its dose-limiting neurotoxicity, whereas Vinblastine’s dose-limiting toxicity is primarily:

7. Paclitaxel, a taxane derivative, exerts its cytotoxic effect by which of the following mechanisms?

8. In the R-CHOP chemotherapy regimen for non-Hodgkin’s lymphoma, the ‘R’ stands for Rituximab, a monoclonal antibody that targets which antigen on B-cells?

9. Tamoxifen is a cornerstone in the treatment of estrogen receptor-positive breast cancer. It belongs to which class of drugs?

10. A patient receiving chemotherapy with Bleomycin must be monitored closely for which potentially fatal, dose-related toxicity?

11. Trastuzumab (Herceptin) is a humanized monoclonal antibody indicated for the treatment of breast and gastric cancers that overexpress which protein?

12. Bevacizumab functions as an anti-cancer agent by targeting and inhibiting the biological activity of:

13. 5-Fluorouracil (5-FU) is a pyrimidine analog that primarily inhibits which enzyme, leading to disruption of DNA synthesis?

14. Irinotecan and Topotecan are camptothecin analogues that induce cell death by inhibiting which enzyme involved in DNA replication and repair?

15. The enzyme L-Asparaginase is a unique chemotherapeutic agent primarily used in the treatment of Acute Lymphoblastic Leukemia (ALL) because leukemic cells:

16. Which of the following drug classes is considered cell cycle-specific, acting primarily during the M phase (mitosis)?

17. In postmenopausal women with hormone receptor-positive breast cancer, drugs like Letrozole and Anastrozole are preferred. What is their mechanism of action?

18. The ‘C’ in the widely used CHOP regimen for lymphoma stands for which of the following cytotoxic agents?

19. Cetuximab is a monoclonal antibody used in the treatment of colorectal and head and neck cancers. Its efficacy is dependent on the tumor expressing which receptor?

20. One of the primary mechanisms by which cancer cells develop resistance to alkylating agents like cyclophosphamide is:

21. Etoposide exerts its antineoplastic effect by targeting which of the following enzymes, leading to DNA strand breaks?

22. All of the following are antimetabolites used in cancer chemotherapy EXCEPT:

23. Bortezomib is a novel agent used in the treatment of multiple myeloma. What is its unique mechanism of action?

24. Colony-Stimulating Factors like Filgrastim (G-CSF) are often administered as supportive care during chemotherapy for what primary purpose?

25. Which of the following is an anti-androgen agent used in the treatment of prostate cancer?