Location of tissues MCQs With Answer is a focused study tool for B. Pharm students who need to master histology and tissue distribution relevant to pharmacology, drug delivery, and pathology. This concise introduction highlights tissue types—epithelial, connective, muscle, and nervous—and their specific anatomical locations such as renal tubules, pulmonary alveoli, hepatic sinusoids, and vascular endothelium. Emphasis is placed on clinically important sites like blood-brain barrier, mucosal linings, and synovial membranes to strengthen understanding of absorption, receptor targets, and drug action. Ideal for exam prep and practical correlation, these targeted MCQs reinforce location-based identification and therapeutic implications. Now let’s test your knowledge with 50 MCQs on this topic.
Q1. Which tissue primarily lines the gastrointestinal tract and is specialized for absorption?
- Simple columnar epithelium
- Stratified squamous epithelium
- Transitional epithelium
- Pseudostratified ciliated columnar epithelium
Correct Answer: Simple columnar epithelium
Q2. Which cell type forms the thin alveolar surface specialized for gas exchange in the lung?
- Type I pneumocyte
- Type II pneumocyte
- Club (Clara) cell
- Alveolar macrophage
Correct Answer: Type I pneumocyte
Q3. The trachea is predominantly lined by which epithelial type?
- Pseudostratified ciliated columnar epithelium with goblet cells
- Simple squamous epithelium
- Stratified keratinized squamous epithelium
- Transitional epithelium
Correct Answer: Pseudostratified ciliated columnar epithelium with goblet cells
Q4. Which specialized cells cover glomerular capillaries with foot processes to form part of the filtration barrier?
- Podocytes (visceral epithelial cells)
- Mesangial cells
- Parietal epithelial cells
- Macula densa cells
Correct Answer: Podocytes (visceral epithelial cells)
Q5. Where are Kupffer cells, the resident macrophages, located?
- Liver sinusoids
- Spleen white pulp
- Bone marrow cavities
- Pulmonary alveoli
Correct Answer: Liver sinusoids
Q6. Which cell resides in lacunae within mineralized bone matrix?
- Osteocyte
- Osteoblast
- Chondrocyte
- Fibroblast
Correct Answer: Osteocyte
Q7. Elastic cartilage, rich in elastic fibers, is typically found in which location?
- External ear (auricle) and epiglottis
- Intervertebral discs
- Articular surfaces of long bones
- Tracheal rings
Correct Answer: External ear (auricle) and epiglottis
Q8. Tendons are composed predominantly of which tissue?
- Dense regular connective tissue
- Loose areolar connective tissue
- Hyaline cartilage
- Elastic connective tissue
Correct Answer: Dense regular connective tissue
Q9. What cell type and structure are principal in forming the blood–brain barrier?
- Endothelial cells with tight junctions
- Astrocytes alone
- Microglia phagocytic processes
- Oligodendrocyte myelin sheaths
Correct Answer: Endothelial cells with tight junctions
Q10. The outermost epidermal layer of the skin is characterized by which epithelium?
- Keratinized stratified squamous epithelium
- Non-keratinized stratified squamous epithelium
- Simple cuboidal epithelium
- Transitional epithelium
Correct Answer: Keratinized stratified squamous epithelium
Q11. The urinary bladder is lined by what specialized epithelium that allows distension?
- Transitional (urothelium)
- Simple columnar epithelium
- Stratified squamous epithelium
- Pseudostratified columnar epithelium
Correct Answer: Transitional (urothelium)
Q12. The endocrine pancreatic islets (Islets of Langerhans) are located within which organ layer?
- Pancreatic parenchyma among acinar cells
- Pancreatic duct lining
- Capsule surrounding the pancreas
- Submucosa of the duodenum
Correct Answer: Pancreatic parenchyma among acinar cells
Q13. Sinusoidal (discontinuous) capillaries are characteristic of which organ facilitating cell traffic?
- Liver (hepatic sinusoids)
- Skin dermis
- Brain cortex
- Cardiac muscle
Correct Answer: Liver (hepatic sinusoids)
Q14. Which renal segment has a prominent brush border of microvilli to increase surface area for reabsorption?
- Proximal convoluted tubule
- Distal convoluted tubule
- Collecting duct
- Loop of Henle thin limb
Correct Answer: Proximal convoluted tubule
Q15. Cardiac muscle, identifiable by branching cells and intercalated discs, is located in the:
- Myocardium of the heart
- Walls of large arteries
- Gastrointestinal tract
- Uterine smooth muscle
Correct Answer: Myocardium of the heart
Q16. Purkinje fibers, important in cardiac conduction, are located in which layer?
- Subendocardial layer of the ventricles
- Epicardium only
- Myocardial capillary beds
- Interatrial septum mucosa
Correct Answer: Subendocardial layer of the ventricles
Q17. Exocrine acinar cells that secrete digestive enzymes are found in which organ?
- Pancreas (exocrine pancreas)
- Thyroid gland
- Adrenal medulla
- Bone marrow
Correct Answer: Pancreas (exocrine pancreas)
Q18. Osteoclasts perform bone resorption and are typically located in what depressions on bone surfaces?
- Howship’s lacunae
- Lacunae housing osteocytes
- Haversian canals
- Endosteal crypts
Correct Answer: Howship’s lacunae
Q19. Goblet cells that secrete mucus are abundant in which mucosal lining?
- Respiratory tract (trachea and bronchi)
- Articular cartilage
- Renal glomerulus
- Thyroid follicular epithelium
Correct Answer: Respiratory tract (trachea and bronchi)
Q20. The synovial membrane lining joints primarily consists of which components?
- Synoviocytes overlying loose connective tissue
- Keratinized stratified squamous epithelium
- Hyaline cartilage only
- Simple squamous mesothelium
Correct Answer: Synoviocytes overlying loose connective tissue
Q21. The esophagus is lined by which epithelial type adapted to abrasion?
- Stratified non-keratinized squamous epithelium
- Simple columnar epithelium
- Transitional epithelium
- Pseudostratified ciliated columnar epithelium
Correct Answer: Stratified non-keratinized squamous epithelium
Q22. Elastic fibers are particularly abundant in which vascular structure to allow recoil?
- Elastic arteries (e.g., aorta)
- Capillaries
- Venous valves
- Arterioles
Correct Answer: Elastic arteries (e.g., aorta)
Q23. Aggregated lymphoid nodules known as Peyer’s patches are most prominent in which intestinal region?
- Ileum
- Duodenum
- Stomach
- Jejunum
Correct Answer: Ileum
Q24. Osteoblasts synthesizing new bone matrix are characteristically located where?
- On the bone surface beneath the periosteum
- Inside lacunae surrounded by matrix
- Within the bone marrow sinusoids
- In the epiphyseal cartilage only
Correct Answer: On the bone surface beneath the periosteum
Q25. A basement membrane is found between which two tissue layers?
- Epithelium and underlying connective tissue
- Two layers of smooth muscle
- Bone and periosteum
- Endothelium and blood plasma
Correct Answer: Epithelium and underlying connective tissue
Q26. Where are microvilli forming a brush border most abundant to aid absorption?
- Small intestinal enterocytes
- Lining of the trachea
- Hepatic sinusoids
- Cardiac endothelium
Correct Answer: Small intestinal enterocytes
Q27. Photoreceptors (rods and cones) are located in which retinal layer?
- Outer nuclear and photoreceptor layer of the neural retina
- Retinal pigment epithelium only
- Inner limiting membrane
- Ganglion cell layer
Correct Answer: Outer nuclear and photoreceptor layer of the neural retina
Q28. Merkel cells, involved in tactile sensation, are found in which epidermal layer?
- Stratum basale
- Stratum corneum
- Stratum lucidum
- Stratum granulosum
Correct Answer: Stratum basale
Q29. Myelin in peripheral nerves is produced by which cells?
- Schwann cells
- Oligodendrocytes
- Astrocytes
- Microglia
Correct Answer: Schwann cells
Q30. Oligodendrocytes, which myelinate CNS axons, are located primarily in which region?
- CNS white matter
- Peripheral nerve sheaths
- Dermal connective tissue
- Synovial membrane
Correct Answer: CNS white matter
Q31. Brown adipose tissue, specialized for non-shivering thermogenesis, is most abundant in which population and region?
- Infants in the interscapular region
- Adult subcutaneous abdominal fat
- Bone marrow of adults
- Dermis of the forearm
Correct Answer: Infants in the interscapular region
Q32. The parietal layer of Bowman’s capsule is lined by which epithelium?
- Simple squamous epithelium
- Simple columnar epithelium
- Stratified squamous epithelium
- Transitional epithelium
Correct Answer: Simple squamous epithelium
Q33. Tight junctions that prevent paracellular leakage are abundant between cells of which tissue?
- Intestinal epithelium (enterocytes)
- Skeletal muscle fibers
- Hyaline cartilage chondrocytes
- Bone osteocytes
Correct Answer: Intestinal epithelium (enterocytes)
Q34. Mucosa-associated lymphoid tissue (MALT) includes structures like the tonsils located in which area?
- Oropharynx
- Peritoneal cavity
- Bone marrow
- Cornea
Correct Answer: Oropharynx
Q35. The cartilaginous rings of the trachea are composed of which cartilage type?
- Hyaline cartilage
- Elastic cartilage
- Fibrocartilage
- Reticular cartilage
Correct Answer: Hyaline cartilage
Q36. The tunica media of large elastic arteries is rich in which tissue element?
- Elastic fibers mixed with smooth muscle
- Dense irregular connective tissue
- Adipose tissue
- Hyaline cartilage
Correct Answer: Elastic fibers mixed with smooth muscle
Q37. Fibrocartilage, resistant to compression, is found in which location?
- Intervertebral discs
- External ear
- Tracheal rings
- Epiphyseal plates
Correct Answer: Intervertebral discs
Q38. Which tissue expresses uncoupling protein 1 (UCP1) and many mitochondria for heat production?
- Brown adipose tissue
- White adipose tissue
- Skeletal muscle
- Liver parenchyma
Correct Answer: Brown adipose tissue
Q39. The uterine (fallopian) tube mucosa is lined by which epithelium to move the ovum?
- Simple ciliated columnar epithelium
- Stratified squamous epithelium
- Transitional epithelium
- Simple squamous epithelium
Correct Answer: Simple ciliated columnar epithelium
Q40. The innermost lining of blood vessels, the tunica intima, is formed by which cell type?
- Simple squamous endothelial cells
- Smooth muscle cells
- Fibroblasts
- Keratinocytes
Correct Answer: Simple squamous endothelial cells
Q41. Intercalated discs are a distinguishing feature of which tissue?
- Cardiac muscle
- Smooth muscle
- Skeletal muscle
- Connective tissue
Correct Answer: Cardiac muscle
Q42. The visceral peritoneum (serosa) is lined by which epithelium?
- Simple squamous mesothelium
- Stratified squamous epithelium
- Simple columnar epithelium
- Pseudostratified columnar epithelium
Correct Answer: Simple squamous mesothelium
Q43. Fenestrated capillaries are commonly found in which of the following locations?
- Renal glomeruli
- Central nervous system
- Skin papillary dermis
- Cartilage lacunae
Correct Answer: Renal glomeruli
Q44. Langerhans cells, antigen-presenting dendritic cells, are located in which epidermal layer?
- Stratum spinosum
- Stratum corneum
- Stratum basale
- Stratum lucidum
Correct Answer: Stratum spinosum
Q45. Which major salivary gland is predominantly serous and secretes α-amylase?
- Parotid gland
- Sublingual gland
- Submandibular gland
- Minor labial glands
Correct Answer: Parotid gland
Q46. In the kidney collecting duct, which cells are primarily responsible for acid–base regulation?
- Intercalated cells
- Principal cells
- Podocytes
- Mesangial cells
Correct Answer: Intercalated cells
Q47. Microglia, the resident immune cells of the CNS, are located in which tissue?
- Central nervous system (brain and spinal cord)
- Peripheral lymph nodes
- Spleen red pulp
- Bone marrow stroma
Correct Answer: Central nervous system (brain and spinal cord)
Q48. Elastic fibers that provide recoil in alveolar walls are found mainly in which lung component?
- Alveolar septa (lung interstitium)
- Pulmonary pleura only
- Bronchial cartilage
- Tracheal epithelium
Correct Answer: Alveolar septa (lung interstitium)
Q49. Mast cells, important in allergic responses, are typically located in which tissue compartment?
- Loose connective tissue near blood vessels
- Hyaline cartilage matrix
- Neuronal cell bodies in CNS
- Hepatic bile canaliculi
Correct Answer: Loose connective tissue near blood vessels
Q50. Satellite glial cells that surround neuronal cell bodies are found in which location?
- Peripheral ganglia (e.g., dorsal root ganglia)
- Cerebral cortex grey matter
- Spinal cord central canal
- Neuromuscular junction synaptic cleft
Correct Answer: Peripheral ganglia (e.g., dorsal root ganglia)
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