Joint Pain & Inflammatory Arthritis MCQ Quiz | Rheumatology & Immunology

1. A 55-year-old woman presents with symmetrical swelling and pain in her metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints, along with morning stiffness lasting over an hour. Which antibody is most specific for her likely condition?

2. A 68-year-old man complains of right knee pain that worsens throughout the day and with activity. He notes brief morning stiffness for about 15 minutes. On examination, you find bony enlargement of the distal interphalangeal (DIP) joints. What is the most likely diagnosis?

3. A 45-year-old male presents with a sudden, excruciatingly painful, red, and swollen first metatarsophalangeal joint. Aspiration of the joint fluid would most likely reveal:

4. A 28-year-old male complains of chronic low back pain and stiffness that is worse in the morning and improves with exercise. Radiographs of the spine show bridging syndesmophytes. Which genetic marker is strongly associated with this condition?

5. Which of the following is considered a first-line disease-modifying antirheumatic drug (DMARD) for the treatment of Rheumatoid Arthritis?

6. A patient with a history of psoriasis presents with asymmetric oligoarthritis, dactylitis (“sausage digit”), and nail pitting. What is the most likely diagnosis?

7. A 25-year-old presents with acute arthritis, conjunctivitis, and urethritis two weeks after a gastrointestinal infection. This triad is characteristic of which condition?

8. A patient presents with a single, hot, swollen, and extremely painful knee joint, accompanied by fever and chills. What is the most crucial initial investigation?

9. The primary pathological process in Osteoarthritis involves the degradation of:

10. Allopurinol is used for the chronic management of gout. What is its mechanism of action?

11. A 30-year-old female presents with a malar rash, photosensitivity, and non-erosive arthritis in her hands and knees. Which of the following is the best initial screening test for her suspected condition?

12. Which of the following is a classic X-ray finding in advanced Osteoarthritis?

13. The triad of rheumatoid arthritis, splenomegaly, and neutropenia is known as:

14. What is the most common causative organism of septic arthritis in sexually active young adults?

15. Ulnar deviation, swan-neck deformity, and boutonnière deformity are characteristic hand findings in which condition?

16. A 75-year-old woman is diagnosed with pseudogout (Calcium Pyrophosphate Dihydrate Deposition Disease). Which joint is most commonly affected?

17. Which of the following medications is most commonly implicated in drug-induced lupus?

18. A key feature distinguishing inflammatory arthritis from non-inflammatory arthritis is:

19. Which condition is NOT considered a seronegative spondyloarthropathy?

20. The most common extra-articular manifestation of Ankylosing Spondylitis is:

21. Heberden’s nodes and Bouchard’s nodes are characteristic findings in:

22. What is the best first-line treatment for an acute gout attack in a patient with no contraindications?

23. In septic arthritis, a synovial fluid white blood cell (WBC) count is typically:

24. Which of the following is a common infectious trigger for Reactive Arthritis?

25. “Bamboo spine” is a characteristic radiological finding in late-stage: