Jaundice MCQ Quiz | Hepatology & Biliary

1. The conjugation of bilirubin primarily occurs in which cellular organelle within the hepatocyte?

2. An isolated rise in unconjugated bilirubin with normal liver enzymes is a characteristic finding in:

3. Which of the following is most characteristic of post-hepatic (obstructive) jaundice?

4. Courvoisier’s law states that a palpably enlarged, non-tender gallbladder in a jaundiced patient is unlikely to be due to:

5. A black or dark-pigmented liver found on biopsy is a pathognomonic feature of:

6. Which form of bilirubin is water-soluble and can be excreted in the urine, causing bilirubinuria?

7. Physiological jaundice of the newborn typically peaks around day 3-5 of life and is primarily due to:

8. Kernicterus, a serious complication of neonatal jaundice, results from the deposition of which substance in the basal ganglia?

9. In a patient with acute viral hepatitis, the liver function test pattern would most likely show:

10. Crigler-Najjar syndrome Type I is a severe neonatal condition characterized by:

11. What is the initial imaging modality of choice for a patient with suspected obstructive jaundice?

12. The substance that gives stool its characteristic brown color is:

13. In pre-hepatic jaundice due to massive hemolysis, what is the expected finding for urinary urobilinogen?

14. A middle-aged woman presents with fatigue, pruritus, and jaundice. Her blood tests show high ALP and positive anti-mitochondrial antibodies (AMA). What is the most likely diagnosis?

15. Drug-induced cholestatic jaundice is a known side effect of which of the following medications?

16. The enzyme responsible for converting heme to biliverdin during red blood cell breakdown is:

17. Charcot’s triad, consisting of right upper quadrant pain, fever, and jaundice, is a classic presentation of:

18. Which of the following is NOT a recognized cause of pre-hepatic jaundice?

19. In complete obstruction of the common bile duct, urinalysis would most likely reveal:

20. What is the mechanism of jaundice in a patient with advanced liver cirrhosis?

21. Both Dubin-Johnson and Rotor syndromes are characterized by conjugated hyperbilirubinemia. How can they be differentiated?

22. Which of the following conditions causes a mixed (both conjugated and unconjugated) hyperbilirubinemia?

23. In the enterohepatic circulation, conjugated bilirubin is deconjugated by gut bacteria into:

24. Jaundice becomes clinically evident when the total serum bilirubin level exceeds approximately:

25. A patient with hemolytic anemia develops jaundice. What is the primary type of hyperbilirubinemia expected?