Jaundice MCQ Quiz | Hepatology & Biliary

Welcome to the Jaundice MCQ Quiz, specifically designed for MBBS students navigating the complexities of Hepatology and Biliary sciences. This quiz will test your understanding of bilirubin metabolism, the pathophysiology of different types of jaundice, and the clinical and biochemical features of key hepatic and biliary disorders. Covering pre-hepatic, hepatic, and post-hepatic causes, from hemolytic anemias to obstructive conditions like choledocholithiasis, this assessment provides a comprehensive review. After submitting your answers, you will receive your score and see a detailed breakdown of the correct and incorrect responses. For your revision, you can also download a PDF copy of all the questions along with their correct answers. Good luck!

1. The conjugation of bilirubin primarily occurs in which cellular organelle within the hepatocyte?

2. An isolated rise in unconjugated bilirubin with normal liver enzymes is a characteristic finding in:

3. Which of the following is most characteristic of post-hepatic (obstructive) jaundice?

4. Courvoisier’s law states that a palpably enlarged, non-tender gallbladder in a jaundiced patient is unlikely to be due to:

5. A black or dark-pigmented liver found on biopsy is a pathognomonic feature of:

6. Which form of bilirubin is water-soluble and can be excreted in the urine, causing bilirubinuria?

7. Physiological jaundice of the newborn typically peaks around day 3-5 of life and is primarily due to:

8. Kernicterus, a serious complication of neonatal jaundice, results from the deposition of which substance in the basal ganglia?

9. In a patient with acute viral hepatitis, the liver function test pattern would most likely show:

10. Crigler-Najjar syndrome Type I is a severe neonatal condition characterized by:

11. What is the initial imaging modality of choice for a patient with suspected obstructive jaundice?

12. The substance that gives stool its characteristic brown color is:

13. In pre-hepatic jaundice due to massive hemolysis, what is the expected finding for urinary urobilinogen?

14. A middle-aged woman presents with fatigue, pruritus, and jaundice. Her blood tests show high ALP and positive anti-mitochondrial antibodies (AMA). What is the most likely diagnosis?

15. Drug-induced cholestatic jaundice is a known side effect of which of the following medications?

16. The enzyme responsible for converting heme to biliverdin during red blood cell breakdown is:

17. Charcot’s triad, consisting of right upper quadrant pain, fever, and jaundice, is a classic presentation of:

18. Which of the following is NOT a recognized cause of pre-hepatic jaundice?

19. In complete obstruction of the common bile duct, urinalysis would most likely reveal:

20. What is the mechanism of jaundice in a patient with advanced liver cirrhosis?

21. Both Dubin-Johnson and Rotor syndromes are characterized by conjugated hyperbilirubinemia. How can they be differentiated?

22. Which of the following conditions causes a mixed (both conjugated and unconjugated) hyperbilirubinemia?

23. In the enterohepatic circulation, conjugated bilirubin is deconjugated by gut bacteria into:

24. Jaundice becomes clinically evident when the total serum bilirubin level exceeds approximately:

25. A patient with hemolytic anemia develops jaundice. What is the primary type of hyperbilirubinemia expected?