GI Pharmacology | Pharmacology | GPAT Mock Test

Welcome to the GI Pharmacology mock test, specifically designed for GPAT aspirants. This quiz contains 25 multiple-choice questions covering key topics such as antacids, anti-secretory drugs, laxatives, anti-diarrheals, emetics, and antiemetics. Each question is crafted to test your core understanding and application of pharmacological principles relevant to the gastrointestinal system. This practice test will help you evaluate your preparation, identify areas for improvement, and build confidence for the main exam. After submitting your answers, you will see your score and a detailed review of each question. You can also download a PDF of all questions with their correct answers for offline revision. Good luck with your preparation!

1. Which of the following is an example of a systemic antacid that can cause metabolic alkalosis upon chronic use?

2. Omeprazole exerts its anti-secretory effect by which of the following mechanisms?

3. Which H2-receptor antagonist is a potent inhibitor of cytochrome P450 enzymes and is known to cause gynecomastia?

4. Ondansetron is a highly effective antiemetic, especially for chemotherapy-induced nausea and vomiting. It acts by blocking:

5. Which of the following drugs is a bulk-forming laxative?

6. Loperamide is an effective antidiarrheal agent that is a synthetic opioid. Why does it lack central analgesic effects at therapeutic doses?

7. The mechanism of action of Sucralfate in healing peptic ulcers is:

8. Orlistat is an anti-obesity drug that functions by:

9. Which drug is a prostaglandin E1 analog used to prevent NSAID-induced gastric ulcers and is absolutely contraindicated in pregnancy?

10. Metoclopramide is a prokinetic agent that also has antiemetic properties. Its prokinetic effect is mediated through:

11. Simethicone is classified as a carminative and acts by:

12. The drug of choice for preventing motion sickness, which acts as a muscarinic receptor antagonist, is:

13. Which of the following is a stool softener that acts as an anionic surfactant?

14. Aprepitant is an antiemetic used for delayed chemotherapy-induced nausea and vomiting. It acts by blocking which receptors in the brain?

15. Which antihistaminic drug, primarily a 5-HT2 antagonist, is also used as an appetite stimulant?

16. Pancrelipase is a digestant used in conditions like pancreatitis. It is a mixture of:

17. A common side effect associated with aluminum-containing antacids is:

18. The standard first-line triple therapy for H. pylori eradication typically includes a proton pump inhibitor and which two antibiotics?

19. Lactulose is an osmotic laxative that is also used in the management of:

20. Domperidone is preferred over Metoclopramide as a prokinetic agent in some cases because it:

21. A centrally acting emetic that is a potent dopamine agonist, administered parenterally for poisoning, is:

22. Bismuth subsalicylate is used for traveler’s diarrhea. A common, harmless side effect is:

23. Proton pump inhibitors like Pantoprazole are administered as enteric-coated tablets because they are:

24. Co-administration of antacids containing divalent or trivalent cations (Mg2+, Al3+, Ca2+) significantly reduces the absorption of which class of antibiotics?

25. Which of the following laxatives belongs to the stimulant/irritant category?