Filariasis MCQ Quiz | Hepatic & Lymphatic Infections

Welcome to the comprehensive MCQ quiz on Filariasis, designed specifically for MBBS students. This quiz covers the essential aspects of lymphatic filariasis, including its etiology, life cycle, clinical manifestations, diagnosis, and management strategies. You will be tested on key pathogens like Wuchereria bancrofti and Brugia malayi, their vectors, and the pathological changes they induce, from acute adenolymphangitis to chronic conditions like elephantiasis and hydrocele. This assessment will help you consolidate your knowledge on this significant tropical disease. After submitting your answers, you’ll receive your score and see the correct answers highlighted. For your revision, you can also download all the questions and their correct answers as a PDF file. Good luck!

1. The most common causative agent of lymphatic filariasis worldwide is:

Wuchereria bancrofti Brugia malayi Loa loa Onchocerca volvulus

2. The infective stage of Wuchereria bancrofti for humans is the:

Microfilaria Adult worm Third-stage (L3) filariform larva Embryonated egg

3. What is the characteristic periodicity of microfilariae of Wuchereria bancrofti in peripheral blood?

Diurnal Nocturnal Sub-periodic Non-periodic

4. Tropical Pulmonary Eosinophilia (TPE) is a form of:

Acute filariasis Chronic filariasis Occult filariasis Asymptomatic microfilaremia

5. The “gold standard” for diagnosing active lymphatic filariasis is:

Detection of microfilariae in a thick blood smear Detection of circulating filarial antigen (CFA) Ultrasound showing the “filarial dance sign” Elevated IgG4 antibody levels

6. Diethylcarbamazine (DEC) is effective against which stages of W. bancrofti?

Only adult worms Only microfilariae Both microfilariae and adult worms Neither, it only suppresses reproduction

7. A severe adverse reaction to DEC treatment, known as the Mazzotti reaction, is caused by:

Direct drug toxicity to the host An allergic reaction to the drug itself Host inflammatory response to antigens from dying microfilariae Neurotoxicity from the drug crossing the blood-brain barrier

8. Which of the following is NOT a chronic manifestation of lymphatic filariasis?

Hydrocele Lymphedema Chyluria Acute dermatolymphangioadenitis (ADLA)

9. The main vector for Wuchereria bancrofti in urban and semi-urban areas is:

Aedes mosquito Culex mosquito Anopheles mosquito Mansonia mosquito

10. Doxycycline is used in the management of filariasis to target:

The microfilariae directly The host’s inflammatory response The endosymbiotic Wolbachia bacteria The mosquito vector’s larvae

11. A key morphological feature to differentiate microfilariae of W. bancrofti from B. malayi is:

The presence of a sheath in B. malayi and absence in W. bancrofti The presence of two terminal nuclei in the tail of B. malayi The cephalic space size The staining characteristics with Giemsa

12. Which component of the WHO’s strategy for eliminating lymphatic filariasis involves providing care for those with chronic disease?

Mass Drug Administration (MDA) Vector Control Morbidity Management and Disability Prevention (MMDP) Integrated Surveillance and Response (ISR)

13. The “filarial dance sign” on high-resolution ultrasound represents:

Movement of microfilariae in blood vessels Twitching of live adult worms within lymphatic vessels Calcified dead worms causing lymphatic obstruction Host immune cells attacking the parasite

14. What is the recommended drug regimen for Mass Drug Administration (MDA) in areas co-endemic for onchocerciasis?

DEC + Albendazole Ivermectin + Albendazole Ivermectin + DEC + Albendazole (IDA) DEC alone

15. The presence of lymph in the urine, known as chyluria, is caused by:

Renal parenchymal damage by microfilariae Rupture of lymphatic vessels into the renal pelvis or urinary tract Direct invasion of the bladder wall by adult worms Secondary bacterial infection of the urinary tract

16. The primary pathology in lymphatic filariasis is due to the presence of:

Circulating microfilariae in the blood Adult worms residing in the lymphatics L3 larvae migrating through the skin Host’s allergic reaction to mosquito saliva

17. In Tropical Pulmonary Eosinophilia (TPE), microfilariae are typically:

Abundant in peripheral blood Absent from peripheral blood but present in lung tissue Found only in skin snips Found in both blood and lung tissue

18. The definitive host in the life cycle of Wuchereria bancrofti is:

Human Culex mosquito Domestic pig Monkey

19. Which concentration technique is commonly used to increase the sensitivity of detecting microfilariae in blood?

Kato-Katz technique Ziehl-Neelsen stain Knott’s concentration technique Baermann funnel technique

20. Elephantiasis is characterized by:

Acute inflammation and fever High levels of circulating microfilariae Gross lymphedema with thickening and hardening of the skin

Milky appearance of the urine

21. The vector for Loa loa, the African eye worm, is:

Tsetse fly (Glossina) Black fly (Simulium) Deer fly (Chrysops) Sandfly (Phlebotomus)

22. Which of the following drugs has significant macrofilaricidal activity against W. bancrofti?

Ivermectin Albendazole Praziquantel Diethylcarbamazine (DEC)

23. In the life cycle of filarial worms, development within the mosquito vector from L1 to L3 larva takes approximately:

1-2 days 10-14 days 1-2 months 6 months

24. What is the most common clinical presentation in men with chronic bancroftian filariasis?

Elephantiasis of the leg Hydrocele Chyluria Tropical Pulmonary Eosinophilia

25. The mechanism of lymphedema in filariasis involves a combination of lymphatic obstruction by worms and:

Immune-mediated lymphatic damage and recurrent bacterial infections Direct venom secretion by adult worms Neurogenic inflammation of lymphatic vessels Arterial insufficiency leading to tissue hypoxia

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

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