Estrogens Progestins & Contraceptives MCQ Quiz | Hormones

Welcome to the MCQ quiz on Estrogens, Progestins, and Contraceptives, a crucial topic in Endocrinology and Pharmacology for MBBS students. This quiz is meticulously designed to test your understanding of the synthesis, mechanism of action, physiological effects, and therapeutic applications of female sex hormones. It also covers the pharmacology of various contraceptive methods, including their mechanisms, efficacy, and adverse effects. Challenge yourself with these 25 questions to consolidate your knowledge and prepare for your examinations. After completing the quiz, you can review your performance and download a PDF containing all the questions along with their correct answers for future revision. Good luck, and may your preparation be as effective as a combined oral contraceptive!

1. Which is the most potent naturally occurring estrogen in humans?

2. The primary mechanism of action of combined oral contraceptives (COCs) is:

3. A 45-year-old woman with an intact uterus is prescribed estrogen for menopausal symptoms. What must be co-administered to prevent endometrial hyperplasia?

4. Which of the following is a Selective Estrogen Receptor Modulator (SERM) used for the treatment of breast cancer?

5. The “morning-after pill” containing Levonorgestrel works primarily by:

6. Mifepristone (RU-486) acts as a competitive antagonist at which receptors?

7. Which progestin has significant antiandrogenic activity, making it useful in treating hirsutism and acne?

8. Clomiphene citrate is used to induce ovulation by:

9. An absolute contraindication for the use of combined oral contraceptives is:

10. Which drug is an aromatase inhibitor used in the treatment of ER-positive breast cancer in postmenopausal women?

11. Progestin-only pills (POPs) or “minipills” primarily work by:

12. Raloxifene is approved for the prevention and treatment of osteoporosis. What is its effect on the endometrium and breast tissue?

13. Ulipristal acetate, used for emergency contraception, is a selective modulator of which receptor?

14. The enzyme responsible for converting androgens to estrogens in ovarian granulosa cells and peripheral tissues is:

15. A major concern with long-term use of depot medroxyprogesterone acetate (DMPA) injections is:

16. The progestin component in COCs primarily contributes to contraception by:

17. Which of these is NOT a recognized non-contraceptive benefit of Combined Oral Contraceptives?

18. The primary source of progesterone during the luteal phase of the menstrual cycle is the:

19. Which synthetic estrogen is most commonly used in combined oral contraceptives due to its high oral bioavailability?

20. In the context of hormone replacement therapy (HRT), the term ‘unopposed estrogen’ refers to:

21. The mechanism of action of copper IUDs is primarily:

22. Which of the following drugs is a pure estrogen receptor antagonist (a SERD – Selective Estrogen Receptor Downregulator)?

23. Breakthrough bleeding is a common side effect, especially during the initial months of using:

24. Danazol, a synthetic steroid, has been used for endometriosis. Its primary mechanism involves:

25. The “two-cell, two-gonadotropin” theory explains steroidogenesis in the ovary. Theca cells produce _______ under _______ stimulation, which then diffuse to granulosa cells.