Estrogens Progestins & Contraceptives MCQ Quiz | Hormones

1. Which is the most potent naturally occurring estrogen in humans?

2. The primary mechanism of action of combined oral contraceptives (COCs) is:

3. A 45-year-old woman with an intact uterus is prescribed estrogen for menopausal symptoms. What must be co-administered to prevent endometrial hyperplasia?

4. Which of the following is a Selective Estrogen Receptor Modulator (SERM) used for the treatment of breast cancer?

5. The “morning-after pill” containing Levonorgestrel works primarily by:

6. Mifepristone (RU-486) acts as a competitive antagonist at which receptors?

7. Which progestin has significant antiandrogenic activity, making it useful in treating hirsutism and acne?

8. Clomiphene citrate is used to induce ovulation by:

9. An absolute contraindication for the use of combined oral contraceptives is:

10. Which drug is an aromatase inhibitor used in the treatment of ER-positive breast cancer in postmenopausal women?

11. Progestin-only pills (POPs) or “minipills” primarily work by:

12. Raloxifene is approved for the prevention and treatment of osteoporosis. What is its effect on the endometrium and breast tissue?

13. Ulipristal acetate, used for emergency contraception, is a selective modulator of which receptor?

14. The enzyme responsible for converting androgens to estrogens in ovarian granulosa cells and peripheral tissues is:

15. A major concern with long-term use of depot medroxyprogesterone acetate (DMPA) injections is:

16. The progestin component in COCs primarily contributes to contraception by:

17. Which of these is NOT a recognized non-contraceptive benefit of Combined Oral Contraceptives?

18. The primary source of progesterone during the luteal phase of the menstrual cycle is the:

19. Which synthetic estrogen is most commonly used in combined oral contraceptives due to its high oral bioavailability?

20. In the context of hormone replacement therapy (HRT), the term ‘unopposed estrogen’ refers to:

21. The mechanism of action of copper IUDs is primarily:

22. Which of the following drugs is a pure estrogen receptor antagonist (a SERD – Selective Estrogen Receptor Downregulator)?

23. Breakthrough bleeding is a common side effect, especially during the initial months of using:

24. Danazol, a synthetic steroid, has been used for endometriosis. Its primary mechanism involves:

25. The “two-cell, two-gonadotropin” theory explains steroidogenesis in the ovary. Theca cells produce _______ under _______ stimulation, which then diffuse to granulosa cells.