Drug Interactions & Combinations in Children MCQ Quiz | Therapeutics

1. Why is the combination of ceftriaxone and calcium-containing intravenous solutions strictly contraindicated in neonates less than 28 days old?

2. A 2-week-old neonate is treated for sepsis. Which antibiotic should be avoided due to its potential to displace bilirubin from albumin, increasing the risk of kernicterus?

3. A 5-year-old child with a viral fever is given aspirin. This combination is strongly discouraged due to the risk of developing which condition?

4. A 6-year-old on long-term valproic acid therapy is prescribed meropenem for a severe infection. What is the most clinically significant interaction?

5. A 7-year-old child is prescribed oral doxycycline. Which of the following should be avoided within 2 hours of taking the medication to prevent a pharmacokinetic interaction?

6. Chloramphenicol use in neonates can lead to “Gray baby syndrome” due to their deficiency in which metabolic process?

7. A child with asthma is using an inhaled corticosteroid and a long-acting beta-agonist (LABA). This combination is therapeutically beneficial because:

8. Fluoroquinolones are generally used with caution in children due to concerns about:

9. A child on digoxin for heart failure is started on clarithromycin for a respiratory infection. The clinician should be vigilant for:

10. The use of promethazine is contraindicated in children under 2 years of age due to the high risk of:

11. A 10-year-old child on warfarin therapy requires an antibiotic for a skin infection. Which of the following is most likely to increase the INR and risk of bleeding?

12. Why are topical corticosteroids absorbed more readily in infants compared to adults, increasing the risk of systemic side effects?

13. Combining an ACE inhibitor with a potassium-sparing diuretic in a child with cardiac disease requires careful monitoring for:

14. A child is receiving theophylline for asthma. Co-administration of which drug can significantly increase theophylline levels and risk of toxicity?

15. Codeine is often avoided in children, especially “ultra-rapid metabolizers” of CYP2D6, due to the risk of:

16. The co-administration of methotrexate and a non-steroidal anti-inflammatory drug (NSAID) in a child can lead to:

17. A 4-year-old child presents with iron poisoning. What is the appropriate chelating agent to administer?

18. The “gasping syndrome” in premature infants is associated with the use of intravenous solutions containing which preservative?

19. A child on phenytoin is prescribed an enteral feeding formula. This combination can lead to:

20. What is the primary reason for combining amoxicillin with clavulanic acid?

21. A child receiving lamotrigine develops a widespread rash after starting valproic acid. This severe adverse reaction is more likely because valproic acid:

22. Loperamide is generally not recommended for infectious diarrhea in young children due to the risk of:

23. Combining linezolid with a selective serotonin reuptake inhibitor (SSRI) in an adolescent can precipitate:

24. A child with tuberculosis is treated with a combination of isoniazid, rifampicin, pyrazinamide, and ethambutol. Rifampicin’s primary role in drug interactions is as a potent:

25. Metoclopramide use in children is associated with an increased risk of which type of adverse effect, especially with high doses or prolonged use?