Diphtheria MCQ Quiz | Respiratory Infections

Welcome to the Diphtheria Multiple-Choice Quiz, specifically designed for MBBS students studying Respiratory Infections. This assessment will test your understanding of the etiology, pathogenesis, clinical features, diagnosis, management, and prevention of diphtheria, a critical topic in microbiology and infectious diseases. The quiz comprises 25 carefully curated questions that reflect the level of detail required for your professional examinations. Engage with each question to solidify your knowledge and identify areas for review. After submitting your answers, you will receive your score and see a detailed breakdown of correct and incorrect responses. You can also download a PDF version of all questions with their correct answers for your offline study and revision.

1. Corynebacterium diphtheriae, the causative agent of diphtheria, is best described as a:

2. The diphtheria toxin exerts its primary cytotoxic effect by which of the following mechanisms?

3. A hallmark clinical finding in pharyngeal diphtheria is the presence of:

4. The gene encoding for diphtheria toxin (tox gene) is introduced into non-toxigenic strains of C. diphtheriae via:

5. Which special stain is used to demonstrate the characteristic metachromatic (volutin) granules in C. diphtheriae?

6. The most critical and immediate therapeutic intervention in a patient with suspected clinical diphtheria is:

7. The “bull neck” appearance associated with severe diphtheria is caused by:

8. The in-vitro precipitation test used to confirm the toxigenicity of a C. diphtheriae isolate is known as:

9. What is the most common cause of mortality in patients with diphtheria?

10. The vaccine used for active immunization against diphtheria contains:

11. Which culture medium is selective for C. diphtheriae and results in the formation of grey-black colonies due to tellurite reduction?

12. The primary role of antibiotic therapy (e.g., penicillin) in diphtheria management is to:

13. The Schick test is an intradermal test used to determine:

14. Neurological complications of diphtheria, such as palatal palsy, typically manifest:

15. A key feature differentiating the diphtheritic pseudomembrane from that of streptococcal tonsillitis is that the diphtheritic membrane:

16. The only known natural reservoir for Corynebacterium diphtheriae is:

17. Which component of the diphtheria toxin is responsible for binding to receptors on the host cell surface?

18. Prophylaxis for an asymptomatic, unvaccinated close contact of a confirmed diphtheria case should include:

19. Cutaneous diphtheria typically presents as:

20. The Tdap vaccine, recommended for adolescents and adults, provides protection against:

21. What is the composition of the pseudomembrane in diphtheria?

22. Myocarditis as a complication of diphtheria is due to:

23. Which of the following describes the characteristic appearance of C. diphtheriae on Gram stain?

24. A patient is treated for severe pharyngeal diphtheria. After recovery, which of the following is recommended?

25. The systemic spread of diphtheria toxin primarily occurs via:

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