Cutaneous Drug Reactions MCQ Quiz | Dermatology (Medical)

1. A 45-year-old male on antiepileptic medication develops a high-grade fever, facial edema, a widespread morbilliform rash, and lymphadenopathy. Blood tests reveal eosinophilia and atypical lymphocytes. Which of the following is the most likely diagnosis?

2. Which of the following cutaneous drug reactions is characterized by the recurrence of a solitary, well-demarcated, erythematous or violaceous plaque at the exact same site upon re-exposure to the offending drug?

3. The SCORTEN score is a validated prognostic tool used for which severe cutaneous adverse reaction?

4. A patient develops widespread, non-follicular, sterile pustules on an erythematous base, accompanied by high fever and neutrophilia, shortly after starting amoxicillin. This clinical picture is most consistent with:

5. The most common type of all cutaneous drug reactions, presenting as a symmetric maculopapular rash, is:

6. ACE inhibitor-induced angioedema is primarily mediated by which substance?

7. A patient develops a painful, purpuric skin lesion that progresses to necrosis on her thigh 4 days after starting warfarin. This is likely due to an initial transient deficiency of:

8. The presence of anti-histone antibodies is highly characteristic of which drug-induced condition?

9. Toxic Epidermal Necrolysis (TEN) is defined by epidermal detachment affecting what percentage of the body surface area (BSA)?

10. Vancomycin is a well-known cause of which specific autoimmune bullous disease?

11. A phototoxic drug reaction, as opposed to a photoallergic one, is characterized by:

12. Which of the following drugs is NOT a common cause of Stevens-Johnson Syndrome?

13. The reactivation of which virus is strongly associated with the pathogenesis of DRESS syndrome?

14. Thiol-containing drugs like captopril and penicillamine are most classically associated with inducing which condition?

15. The “Nikolsky sign,” where gentle rubbing of the skin causes epidermal separation, is a characteristic finding in:

16. Which of the following drug classes is commonly implicated in causing lichenoid drug eruptions?

17. Drug-induced urticaria is most commonly a Type I hypersensitivity reaction mediated by:

18. A key distinguishing feature of serum sickness-like reaction (e.g., from cefaclor) from true serum sickness is:

19. Which of the following is considered the first and most crucial step in managing any severe cutaneous adverse reaction (SCAR)?

20. SJS/TEN overlap syndrome is defined by epidermal detachment affecting what percentage of the body surface area (BSA)?

21. Erythema multiforme major is distinguished from SJS by:

22. The primary mechanism underlying SJS/TEN involves widespread keratinocyte apoptosis mediated by:

23. Acute Febrile Neutrophilic Dermatosis (Sweet’s Syndrome) can be induced by which of the following agents?

24. What is the typical latency period (time from drug initiation to symptom onset) for DRESS syndrome?

25. A patient on tetracycline for acne develops a severe sunburn-like reaction after minimal sun exposure. This is an example of what type of reaction?