Connective Tissue MCQ Quiz | Microanatomy

1. Which cell is considered the principal cell of connective tissue proper, responsible for synthesizing the extracellular matrix?

2. Which type of collagen fiber provides the most significant tensile strength to tissues like tendons and ligaments?

3. The ground substance of connective tissue is primarily composed of:

4. Upon degranulation, mast cells release granules containing which vasoactive and anticoagulant substances?

5. The matrix of hyaline cartilage is characterized by the presence of which type of collagen?

6. Elastic fibers, which provide recoil to tissues, are best visualized with which special stain?

7. The characteristic “signet ring” appearance, where the nucleus is pushed to the periphery, is seen in which cell?

8. Which of the following is a classic example of dense regular connective tissue?

9. Plasma cells, which are responsible for producing antibodies, are terminally differentiated from which cell type?

10. Reticular fibers, composed of Type III collagen, form a delicate supporting framework (stroma) in which of the following?

11. The perichondrium, a layer of dense irregular connective tissue, is notably absent in:

12. The primary function of macrophages within connective tissue is:

13. Which glycosaminoglycan (GAG) is unique because it is exceptionally large and is not sulfated or covalently linked to a protein core to form a proteoglycan?

14. All adult connective tissues are derived from which embryonic tissue?

15. Scurvy results from a deficiency in Vitamin C, which impairs the function of prolyl hydroxylase. This directly affects the proper synthesis and stability of:

16. The basal lamina, a key component of the basement membrane, is primarily composed of which type of collagen?

17. Which cell is responsible for synthesizing and maintaining the extracellular matrix of cartilage?

18. Loose (areolar) connective tissue is histologically characterized by:

19. Marfan syndrome is a genetic disorder affecting the gene for fibrillin-1. This defect primarily compromises the integrity of:

20. The process of bone formation that occurs directly within a mesenchymal condensation, as seen in the flat bones of the skull, is called:

21. Which of the following is considered a transient (wandering) cell of connective tissue, rather than a resident (fixed) cell?

22. The Haversian system, or osteon, is the fundamental structural unit of:

23. Which statement is TRUE regarding fibrocartilage, found in intervertebral discs and pubic symphysis?

24. A large, ovoid cell with an eccentric nucleus displaying a “clock-face” or “cartwheel” pattern of heterochromatin is characteristic of a:

25. Among the following specialized connective tissues, which one has the most limited capacity for regeneration and repair due to its avascular nature?