Cell-Mediated Immunity MCQ Quiz | Immunology

Welcome to the Cell-Mediated Immunity (CMI) quiz, designed for MBBS students. This quiz will test your understanding of the essential components and processes of CMI, a critical arm of the adaptive immune system. You will face 25 multiple-choice questions covering T-cell biology, antigen presentation, cytotoxic and helper T-cell functions, and the clinical relevance of CMI in infections, autoimmunity, and transplantation. This is a great opportunity to reinforce your immunology knowledge. After submitting your answers, your score will be displayed, and each question will be marked to show the correct and incorrect responses. You can also download a PDF copy of all questions with their correct answers for your future reference and study. Good luck!

1. Which of the following is the primary cell type responsible for killing virus-infected host cells?

2. MHC Class I molecules present antigens to which type of T cell?

3. The co-stimulatory signal required for T-cell activation involves the interaction between:

4. The Th1 subset of helper T cells is primarily characterized by the production of which cytokine?

5. Granzyme B, released by Cytotoxic T Lymphocytes, induces apoptosis in target cells primarily by activating:

6. Which molecule on the surface of a T cell recognizes the peptide-MHC complex on an antigen-presenting cell?

7. Delayed-type hypersensitivity (DTH), such as the tuberculin skin test, is mediated by:

8. Regulatory T cells (Tregs) are crucial for maintaining self-tolerance and typically express which transcription factor?

9. The Fas ligand (FasL) expressed on activated CTLs interacts with Fas on a target cell to induce:

10. Antigen-presenting cells (APCs) present exogenous antigens on which type of MHC molecule?

11. Which cytokine is essential for the proliferation and differentiation of T cells, often called a T-cell growth factor?

12. The “cross-presentation” pathway allows dendritic cells to present exogenous antigens on:

13. Which cell type is NOT considered a professional antigen-presenting cell (APC)?

14. The differentiation of naive T helper cells into the Th17 subset is promoted by which cytokine milieu?

15. Central tolerance for T cells, involving negative selection, occurs in which organ?

16. Which of the following is NOT a primary mechanism used by Cytotoxic T Lymphocytes (CTLs) to kill target cells?

17. Acute cellular rejection of a solid organ transplant is primarily mediated by:

18. The interaction between CD40L on an activated T helper cell and CD40 on an APC is crucial for:

19. Memory T cells differ from naive T cells in that they:

20. Which cytokine produced by Th2 cells is critical for promoting B-cell class switching to IgE and activating M2 macrophages?

21. Superantigens cause massive, non-specific T-cell activation by linking:

22. The term “MHC restriction” refers to the fact that a T-cell receptor recognizes:

23. Which cytokine is known for its role in recruiting neutrophils and is a hallmark of the Th17 response?

24. T-cell anergy is a state of unresponsiveness induced by:

25. In the context of tumor immunology, CTLs recognize and kill tumor cells that present tumor-associated antigens on: