Cell-Mediated & Humoral Responses MCQ Quiz | Immunology

1. Which of the following protein complexes is primarily responsible for presenting endogenous antigens, such as viral proteins, to CD8+ T cells?

2. Exogenous antigens, such as bacteria phagocytosed by a macrophage, are processed and presented on the cell surface by:

3. The second signal required for T-cell activation, which provides co-stimulation and prevents anergy, is primarily mediated by the interaction between:

4. The primary cell type responsible for producing and secreting antibodies during a humoral immune response is the:

5. Which antibody isotype is the first to be produced during a primary immune response and exists as a pentamer?

6. The principal effector cell of cell-mediated immunity that directly kills virus-infected cells and tumor cells is the:

7. Cytotoxic T lymphocytes induce apoptosis in target cells primarily through the release of which two molecules?

8. A T helper cell that secretes IFN-γ and is crucial for activating macrophages to kill intracellular pathogens is characteristic of which subset?

9. The process by which antibodies, particularly IgG, coat a pathogen to enhance its phagocytosis is known as:

10. T-cell dependent B-cell activation requires a crucial interaction for class switching and memory B-cell formation. This interaction is between:

11. Compared to a primary immune response, a secondary (anamnestic) response is characterized by:

12. The process that leads to an increased affinity of antibodies for their antigen during the course of a humoral response is known as:

13. Which antibody class is primarily responsible for providing mucosal immunity by being secreted into the lumen of the gastrointestinal and respiratory tracts?

14. Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism where Fc receptors on an effector cell bind to antibodies attached to a target cell. A classic example involves:

15. T-independent antigens, such as bacterial lipopolysaccharide (LPS), can activate B cells without T-cell help. The response to these antigens typically results in the production of:

16. A Th2-dominant immune response, characterized by the secretion of IL-4, IL-5, and IL-13, is most effective against:

17. Which subset of CD4+ T cells is primarily involved in immune suppression and maintaining self-tolerance, often by producing TGF-β and IL-10?

18. Which of the following cells is considered the most potent professional antigen-presenting cell (APC) for activating naive T cells?

19. The cytokine primarily responsible for the proliferation and survival of activated T cells, acting in an autocrine and paracrine manner, is:

20. A lymphocyte that matures in the thymus and expresses a T-cell receptor (TCR), CD3, and either CD4 or CD8 is a:

21. Central tolerance for T cells, involving the elimination of self-reactive thymocytes through negative selection, occurs in which organ?

22. The region of an antibody molecule responsible for binding to a specific antigen epitope is the:

23. Which two antibody isotypes are most effective at activating the classical pathway of the complement system?

24. Besides the perforin/granzyme system, CTLs can induce apoptosis in target cells through another major pathway involving the interaction of:

25. T follicular helper (Tfh) cells are specialized in providing help to B cells within the germinal centers of lymph nodes, a process essential for: