Calibration | Pharmaceutical Analysis | GPAT Mock Test

Welcome to the GPAT mock test on the Calibration of Analytical Instruments. This quiz is specifically designed to help you master a crucial topic in Pharmaceutical Analysis. It covers the principles and practical aspects of calibrating essential laboratory instruments like UV-Vis Spectrophotometers, HPLC systems, pH meters, and more. You’ll encounter 25 multiple-choice questions that mirror the GPAT exam pattern, testing your understanding of concepts like IQ, OQ, PQ, and system suitability. After completing the quiz, you can submit your answers to see your score and review the correct solutions. For your convenience, you can also download all the questions along with their correct answers in a PDF format for future revision. Good luck!

1. Which of the following is commonly used for the wavelength accuracy calibration of a UV-Visible Spectrophotometer in the UV region?

2. Calibration of a pH meter is typically performed using:

3. A polystyrene film is a standard reference material for calibrating which instrument’s wavenumber accuracy?

4. In HPLC, injector precision is checked by:

5. The qualification phase that documents that an instrument has been delivered and installed in accordance with the manufacturer’s specifications is called:

6. The photometric accuracy of a UV-Visible spectrophotometer is checked using:

7. Disodium tartrate dihydrate is a primary standard used for standardizing:

8. Analytical balance calibration is performed using:

9. System Suitability Test (SST) in chromatography is performed to:

10. The ability of an analytical method to produce results that are directly proportional to the concentration of the analyte within a given range is known as:

11. Operational Qualification (OQ) for an HPLC system would typically include checking:

12. Stray light in a spectrophotometer can be checked using a solution of:

13. The Limit of Quantitation (LOQ) is typically determined as the concentration where the signal-to-noise ratio is:

14. What is used to calibrate a refractometer?

15. Performance Qualification (PQ) of an instrument is intended to:

16. The resolution of a UV-Visible spectrophotometer can be checked using:

17. A standard quartz plate is used to calibrate a:

18. The closeness of agreement between a series of measurements obtained from multiple samplings of the same homogeneous sample under the stipulated conditions is known as:

19. In Gas Chromatography (GC), column performance is often evaluated by calculating the:

20. The mechanical calibration of a dissolution test apparatus (USP Apparatus 1 and 2) involves checking parameters like vessel dimensions, paddle/basket wobble, and rotation speed. Chemical calibration is done using:

21. The lowest amount of an analyte in a sample that can be detected but not necessarily quantitated as an exact value is the:

22. The flow rate accuracy of an HPLC pump is often verified gravimetrically by:

23. In validation, “accuracy” refers to:

24. What is the primary purpose of calibrating a melting point apparatus?

25. Which parameter is NOT typically a part of a chromatographic system suitability test?