About This Calculator

The Bimzelx (bimekizumab) Dosing Calculator is a clinical support tool for healthcare professionals to determine the appropriate dosing schedule for adult patients based on indication and, where applicable, patient weight. It provides a clear timeline for the induction and maintenance phases of treatment according to the U.S. Prescribing Information.

Outputs Explained

After entering the required patient information, the calculator will generate a detailed and personalized dosing schedule. Key outputs include:

• Dosing Summary: Displays the selected indication, recommended dose strength, and patient weight category if relevant.
• Induction Phase Schedule: A table outlining the dose, administration details (e.g., number of injections), and specific calendar dates for each dose from Week 0 to Week 16.
• Maintenance Phase Guidance: A clear description of the recommended dosing interval and strength for long-term treatment starting after Week 16.

How to Use the Calculator

1. Select Indication: Choose the appropriate FDA-approved indication for Bimzelx from the dropdown menu (Plaque Psoriasis, Psoriatic Arthritis, etc.).
2. Enter Patient Weight: Input the patient's current weight. You can enter the value in either kilograms (kg) or pounds (lbs). This is critical for determining the maintenance dose for Plaque Psoriasis.
3. Set Treatment Start Date: Select the date the patient will receive their first dose (Week 0). The calculator will use this to project all future administration dates.

Dosing Overview

The recommended dosing for Bimzelx is administered via subcutaneous injection and varies by indication.

Plaque Psoriasis (PsO)

• Induction (Weeks 0, 4, 8, 12, 16): 320 mg (administered as two 160 mg injections).
• Maintenance (after Week 16): Dosing is based on patient weight.
  • For patients weighing less than 120 kg (<265 lbs): 320 mg every 8 weeks.
  • For patients weighing 120 kg or more (≥265 lbs): 320 mg every 4 weeks.

Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS), and nr-axSpA

• Induction (Weeks 0, 4, 8, 12, 16): 160 mg (administered as one 160 mg injection).
• Maintenance (after Week 16): 160 mg every 4 weeks.

Switching Therapies

This tool does not provide guidance for patients switching to Bimzelx from another biologic or systemic therapy. The decision to initiate Bimzelx, including determining an appropriate washout period from prior treatments, must be based on the treating clinician's judgment and a thorough review of the full Prescribing Information.

Missed Dose Information

This calculator does not provide recommendations for missed doses. If a patient misses a dose, instruct them to inject it as soon as they remember. Subsequently, their treatment schedule should be adjusted to maintain the correct interval. For specific guidance, always consult the full Prescribing Information.

Safety Alerts

Frequently Asked Questions

Why is patient weight important for Plaque Psoriasis dosing?

For Plaque Psoriasis, the maintenance dosing frequency after Week 16 depends on body weight. Patients weighing 120 kg or more require a more frequent administration (every 4 weeks) compared to those under 120 kg (every 8 weeks) to maintain efficacy.

What is the maintenance dose for Psoriatic Arthritis?

The recommended maintenance dose for Psoriatic Arthritis is 160 mg (one injection) administered every 4 weeks, beginning after the initial induction phase is complete at Week 16.

Does the calculator provide guidance for patients with concomitant PsO and PsA?

No. For patients with both Psoriatic Arthritis and moderate to severe Plaque Psoriasis, the recommended dosage is 320 mg. This tool requires selecting a single primary indication. Clinical judgment is required; consult the Prescribing Information for details.

Can I use this tool for pediatric patients?

No. This tool is based on the dosing recommendations for adults. The safety and effectiveness of Bimzelx have not been established in pediatric patients.

How is Bimzelx administered?

Bimzelx is administered by subcutaneous injection. A 320 mg dose requires two separate 160 mg injections. A 160 mg dose requires one injection.

Does this calculator account for loading doses?

Yes, the schedule from Week 0 to Week 16 represents the initial induction (loading) phase of treatment.

What if my patient's start date is in the past?

The tool can calculate a schedule based on a past start date, which can be useful for verifying a patient's treatment timeline and projecting future dose dates.

Is this tool a substitute for the official Prescribing Information?

No. This tool is for educational and informational purposes only and is not a substitute for clinical judgment. Healthcare professionals must always consult the full, most current Prescribing Information before making any treatment decisions.

References

1. BIMZELX® (bimekizumab-bkzx) US Prescribing Information. UCB, Inc. Revised: 10/2023.
2. FDA. Drugs@FDA: BIMZELX (bimekizumab-bkzx). Accessed on current date.
3. European Medicines Agency. Bimzelx (bimekizumab) Summary of Product Characteristics. Accessed on current date.
4. BIMZELX® for Healthcare Professionals. UCB, Inc. Accessed on current date.