Benign Bone Tumors – Diagnosis & Principles MCQ Quiz | Tumors

Quiz Introduction

Welcome to this comprehensive quiz on the Diagnosis and Principles of Benign Bone Tumors, designed specifically for MBBS students. This quiz will test your understanding of the clinical presentation, radiographic features, histology, and management strategies for common benign bone neoplasms. Covering key entities such as Osteochondroma, Giant Cell Tumors, and Osteoid Osteoma, these 25 multiple-choice questions will help you solidify your orthopedic oncology knowledge. After completing the quiz, you can review your performance, see the correct answers highlighted, and check your total score. For your convenience and future revision, you can also download all the questions along with their correct answers in a PDF format. Good luck!

1. A 15-year-old boy presents with a painless, hard mass near his knee. An X-ray reveals a cartilage-capped bony projection arising from the surface of the distal femur. What is the most likely diagnosis?

Osteoid Osteoma Osteochondroma Enchondroma Giant Cell Tumor

2. A 20-year-old male complains of severe, localized pain in his leg that is worse at night and characteristically relieved by aspirin. A CT scan shows a small, well-demarcated lesion (nidus) surrounded by dense reactive bone. What is the diagnosis?

Osteoid Osteoma Chondroblastoma Fibrous Dysplasia Aneurysmal Bone Cyst

3. A 25-year-old female presents with pain and swelling around her knee. An X-ray shows an eccentric, lytic lesion in the epiphysis of the distal femur with a characteristic “soap bubble” appearance. This description is classic for which tumor?

Non-ossifying Fibroma Simple Bone Cyst Giant Cell Tumor (GCT) Osteochondroma

4. Multiple enchondromas, a condition known as Ollier’s disease, significantly increase the risk of malignant transformation into which of the following?

Osteosarcoma Chondrosarcoma Ewing’s Sarcoma Fibrosarcoma

5. An MRI of a painful, expansile bone lesion in an adolescent reveals multiple cystic cavities with fluid-fluid levels. This finding is highly suggestive of:

Fibrous Dysplasia Unicameral Bone Cyst Non-ossifying Fibroma Aneurysmal Bone Cyst (ABC)

6. A “fallen leaf” sign on an X-ray, where a fragment of cortical bone is seen in the dependent portion of a cystic lesion, is pathognomonic for:

Simple (Unicameral) Bone Cyst Aneurysmal Bone Cyst Giant Cell Tumor Chondroblastoma

7. The “ground-glass” appearance on radiography is a classic finding in which benign bone condition?

Osteoid Osteoma Enchondroma Fibrous Dysplasia Non-ossifying Fibroma

8. Which of the following benign tumors is typically found in the epiphysis of long bones in skeletally immature patients and shows “chicken-wire” calcification on histology?

Giant Cell Tumor Chondroblastoma Osteoblastoma Simple Bone Cyst

9. What is the most common primary benign bone tumor?

Giant Cell Tumor Enchondroma Non-ossifying Fibroma Osteochondroma

10. A non-ossifying fibroma (fibrous cortical defect) is a common, asymptomatic lesion found in children. What is the standard management for this lesion if found incidentally?

Surgical excision Observation and reassurance Biopsy and curettage Radiation therapy

11. Maffucci’s syndrome is characterized by the presence of multiple enchondromas and which other type of lesion?

Café-au-lait spots Soft tissue hemangiomas Neurofibromas Precocious puberty

12. Histological examination of a Giant Cell Tumor of bone would primarily reveal mononuclear stromal cells and numerous:

Spindle cells in a storiform pattern Osteoclast-like giant cells Small round blue cells Hyaline cartilage lobules

13. The “Shepherd’s crook” deformity of the proximal femur is a classic finding associated with which condition?

Polyostotic Fibrous Dysplasia Ollier’s Disease Paget’s Disease of Bone Hereditary Multiple Exostoses

14. Which benign bone tumor is typically located in the posterior elements (vertebral arch) of the spine?

Enchondroma Osteochondroma Osteoblastoma Chondroblastoma

15. The “ring and arc” pattern of calcification seen on radiographs is most characteristic of which type of tumor matrix?

Osteoid matrix Fibrous matrix Chondroid (cartilaginous) matrix Cystic fluid

16. The most appropriate treatment for a symptomatic osteoid osteoma that has failed conservative management is:

Wide en-bloc resection Radiofrequency ablation (RFA) External beam radiation Long-term bisphosphonate therapy

17. Histology of fibrous dysplasia shows irregular trabeculae of woven bone in a fibrous stroma, often described as having a pattern resembling:

Herringbone pattern Storiform pattern Chinese characters Onion-skin pattern

18. Denosumab, a monoclonal antibody targeting RANKL, is used as a neoadjuvant or primary treatment for which of these locally aggressive benign tumors?

Aneurysmal Bone Cyst Giant Cell Tumor Chondroblastoma Osteoblastoma

19. Which benign tumor is most commonly found in the small bones of the hands and feet?

Osteoid Osteoma Osteochondroma Enchondroma Giant Cell Tumor

20. Simple bone cysts are most frequently located in the:

Epiphysis of long bones Metaphysis of long bones, such as the proximal humerus or femur Diaphysis of small bones in the hand Posterior elements of the spine

21. An osteoblastoma is histologically similar to an osteoid osteoma but is differentiated primarily by its:

Size (typically > 2 cm) Location in the epiphysis Pain response to NSAIDs Presence of a cartilaginous cap

22. The triad of polyostotic fibrous dysplasia, café-au-lait spots, and precocious puberty is known as:

Ollier’s disease Maffucci’s syndrome McCune-Albright syndrome Gardner’s syndrome

23. Which of the following is NOT a typical feature of a benign bone tumor on an X-ray?

Well-defined geographic margin with sclerosis Wide zone of transition No associated soft tissue mass Solid, non-aggressive periosteal reaction

24. A key diagnostic principle for bone tumors is that Giant Cell Tumors almost exclusively occur in:

Skeletally immature individuals (< 18 years) The diaphysis of long bones Skeletally mature individuals (closed physes) Flat bones such as the pelvis and scapula

25. Which of the following statements about osteochondromas is TRUE?

They typically grow towards the nearest joint. Malignant transformation is common in solitary lesions. They typically stop growing after skeletal maturity. They are composed of fibrous tissue and woven bone.

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

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