Benazepril hydrochloride MCQs With Answer

Benazepril hydrochloride MCQs With Answer offers B.Pharm students a focused review of benazepril’s pharmacology, mechanism, therapeutic uses, pharmacokinetics, dosing, adverse effects, contraindications, and clinically important drug interactions. This set emphasizes key concepts such as conversion to the active metabolite benazeprilat, ACE inhibition, renal considerations, monitoring parameters, and management of side effects like cough, hyperkalemia, and angioedema. Questions are designed to deepen understanding for safe dispensing, counseling, and therapeutic decision-making in hypertension, heart failure, and diabetic nephropathy. The language is concise and exam-oriented to help you master essentials for university and practical pharmacy exams. ‘Now let’s test your knowledge with 30 MCQs on this topic.’

Q1. Which pharmacological class does benazepril hydrochloride belong to?

• Angiotensin II receptor blocker (ARB)
• Calcium channel blocker
• ACE inhibitor
• Beta blocker

Correct Answer: ACE inhibitor

Q2. Benazepril is converted in the body to which active metabolite?

• Enalaprilat
• Benazeprilat
• Lisinoprilat
• Captopril

Correct Answer: Benazeprilat

Q3. What is the primary mechanism of action of benazepril?

• Blockade of beta-1 adrenergic receptors
• Inhibition of angiotensin converting enzyme, reducing angiotensin II formation
• Calcium channel blockade in vascular smooth muscle
• Stimulation of alpha-2 adrenergic receptors

Correct Answer: Inhibition of angiotensin converting enzyme, reducing angiotensin II formation

Q4. For which of the following indications is benazepril commonly prescribed?

• Type 1 diabetes as first-line insulin therapy
• Hypertension and heart failure
• Acute myocardial infarction thrombolysis
• Anticoagulation in atrial fibrillation

Correct Answer: Hypertension and heart failure

Q5. Which of the following is a contraindication to benazepril therapy?

• Controlled hypertension with no comorbidities
• Pregnancy, especially in second and third trimester
• Stable chronic cough not related to drugs
• Mild osteoarthritis

Correct Answer: Pregnancy, especially in second and third trimester

Q6. The persistent dry cough associated with benazepril is primarily due to accumulation of which mediator?

• Histamine
• Prostaglandin E2
• Bradykinin
• Substance P

Correct Answer: Bradykinin

Q7. Which serious allergic-like adverse effect can occur with benazepril and requires immediate discontinuation?

• Stevens-Johnson syndrome
• Angioedema
• Drug-induced lupus
• Agranulocytosis

Correct Answer: Angioedema

Q8. What laboratory abnormality is commonly associated with ACE inhibitor therapy like benazepril?

• Hypokalemia
• Hyperkalemia
• Elevated alkaline phosphatase only
• Decreased serum creatinine

Correct Answer: Hyperkalemia

Q9. Which drug interaction can reduce the antihypertensive effect of benazepril?

• Concurrent use of thiazide diuretics
• Concurrent use of NSAIDs (long-term)
• Concurrent use of amlodipine
• Concurrent use of spironolactone only

Correct Answer: Concurrent use of NSAIDs (long-term)

Q10. Combining benazepril with which of the following increases the risk of hyperkalemia?

• Loop diuretics
• Potassium supplements or potassium-sparing diuretics
• Calcium supplements
• Thyroid hormone replacement

Correct Answer: Potassium supplements or potassium-sparing diuretics

Q11. A commonly recommended initial oral dose of benazepril for adult hypertension is:

• 1 mg once daily
• 10 mg once daily
• 100 mg twice daily
• 50 mg every 6 hours

Correct Answer: 10 mg once daily

Q12. Regarding renal impairment, benazepril dosing should be:

• Increased in severe renal impairment
• Avoided only in mild renal impairment
• Adjusted or used with caution in severe renal impairment
• No adjustment needed for any degree of renal impairment

Correct Answer: Adjusted or used with caution in severe renal impairment

Q13. Benazepril is a prodrug that is activated primarily by:

• Renal tubular enzymes
• Plasma and hepatic esterases to form benazeprilat
• Gut microbial metabolism only
• Oxidative CYP450 metabolism exclusively

Correct Answer: Plasma and hepatic esterases to form benazeprilat

Q14. The primary route of elimination for benazeprilat (active metabolite) is:

• Renal excretion
• Exhalation via lungs
• Biliary excretion only
• Sweat and saliva

Correct Answer: Renal excretion

Q15. Typical onset of antihypertensive action after oral benazepril administration occurs within:

• 1 hour
• 24 hours
• 48–72 hours only
• One week

Correct Answer: 1 hour

Q16. ACE inhibitors like benazepril slow progression of diabetic nephropathy primarily by:

• Increasing intraglomerular pressure
• Lowering glomerular filtration rate irreversibly
• Reducing efferent arteriolar constriction and intraglomerular pressure
• Stimulating renin release exclusively

Correct Answer: Reducing efferent arteriolar constriction and intraglomerular pressure

Q17. Combining an ACE inhibitor such as benazepril with an ARB (angiotensin receptor blocker) is generally:

• Recommended for all hypertensive patients
• Contraindicated in pregnancy only
• Associated with increased risk of hyperkalemia and renal dysfunction and usually avoided
• Useful to prevent cough

Correct Answer: Associated with increased risk of hyperkalemia and renal dysfunction and usually avoided

Q18. Coadministration of benazepril with lithium may lead to:

• Decreased lithium levels and loss of efficacy
• No interaction
• Increased lithium levels and risk of lithium toxicity
• Enhanced renal clearance of lithium

Correct Answer: Increased lithium levels and risk of lithium toxicity

Q19. ACE inhibitors are contraindicated or should be used with extreme caution in patients with:

• Unilateral renal artery stenosis
• History of seasonal allergies only
• Stable angina with normal renal function
• Bilateral renal artery stenosis

Correct Answer: Bilateral renal artery stenosis

Q20. What baseline and follow-up monitoring is essential when initiating benazepril?

• Complete blood count every week only
• Liver function tests exclusively
• Serum creatinine and serum potassium
• Fasting blood glucose daily

Correct Answer: Serum creatinine and serum potassium

Q21. Which clinical situation increases the risk of symptomatic hypotension after the first dose of benazepril?

• Volume depletion or diuretic therapy
• Concurrent beta blocker at low dose
• Taking the drug with food
• Age under 18 years

Correct Answer: Volume depletion or diuretic therapy

Q22. ACE is also known as kininase II. Inhibition of this enzyme by benazepril leads to increased levels of:

• Angiotensin II only
• Bradykinin
• Aldosterone only
• Renin degradation products exclusively

Correct Answer: Bradykinin

Q23. Does food significantly affect the oral absorption of benazepril?

• Yes — food completely prevents absorption
• No — food does not significantly affect absorption
• Yes — food doubles absorption always
• Food converts benazepril to an inactive form

Correct Answer: No — food does not significantly affect absorption

Q24. Exposure of a fetus to ACE inhibitors like benazepril during the second and third trimesters can cause:

• Neural tube defects exclusively
• Oligohydramnios and fetal renal impairment
• Increased fetal growth
• No known fetal effects

Correct Answer: Oligohydramnios and fetal renal impairment

Q25. The hydrochloride in benazepril hydrochloride refers to:

• An ester impurity
• The salt form used to make an oral formulation
• The active metabolite
• A transporter protein

Correct Answer: The salt form used to make an oral formulation

Q26. The cough produced by benazepril typically:

• Is productive with purulent sputum
• Is dry, nonproductive, and often resolves after stopping the drug
• Is an immediate anaphylactic event
• Indicates bacterial pneumonia in all cases

Correct Answer: Is dry, nonproductive, and often resolves after stopping the drug

Q27. Activation of benazepril to benazeprilat occurs primarily by which biochemical process?

• Hydrolysis of an ester linkage
• Direct gamma-glutamyl transfer
• Decarboxylation by gut flora only
• Conjugation with glucuronic acid

Correct Answer: Hydrolysis of an ester linkage

Q28. How does benazepril affect aldosterone secretion?

• It increases aldosterone secretion
• It has no effect on aldosterone
• It decreases aldosterone secretion by lowering angiotensin II
• It directly stimulates aldosterone receptors

Correct Answer: It decreases aldosterone secretion by lowering angiotensin II

Q29. A common, less severe adverse effect patients may report on benazepril therapy is:

• Persistent hyperactivity
• Dizziness, especially on standing
• Excessive hair growth
• Excessive salivation only at night

Correct Answer: Dizziness, especially on standing

Q30. Use of benazepril in combination with aliskiren is specifically advised against in patients with:

• Well-controlled hypertension under age 50
• Diabetes mellitus or renal impairment
• Isolated hyperlipidemia only
• Migraine headaches

Correct Answer: Diabetes mellitus or renal impairment

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

Mail- Sachin@pharmacyfreak.com