1. Which antimalarial drug is contraindicated in patients with G6PD deficiency due to the risk of inducing severe hemolysis?
2. The primary mechanism of action of Chloroquine involves:
3. Which class of antimalarial drugs, known for their rapid schizonticidal action, is derived from a Chinese herb?
4. A patient returning from a trip to Africa develops fever and is diagnosed with severe P. falciparum malaria. Which of the following is the most appropriate parenteral treatment?
5. The term ‘radical cure’ in the context of malaria refers to the eradication of which parasitic form?
6. Cinchonism, characterized by tinnitus, headache, and visual disturbances, is a classic adverse effect of:
7. Atovaquone-proguanil (Malarone) acts by inhibiting which two distinct pathways in the malaria parasite?
8. Which antimalarial is known for causing significant neuropsychiatric adverse effects, including vivid dreams, anxiety, and psychosis?
9. For chemoprophylaxis in a region with chloroquine-resistant P. falciparum, which of the following is a suitable first-line option?
10. The primary therapeutic use of an 8-aminoquinoline like primaquine is for:
11. Artemisinin Combination Therapies (ACTs) are the standard of care for uncomplicated P. falciparum malaria. Why are they used in combination?
12. Which of the following drugs acts on the blood schizonts and is also a potent gametocidal agent against all Plasmodium species, making it useful for interrupting transmission?
13. Blackwater fever, a severe clinical syndrome involving massive intravascular hemolysis, is historically associated with the use of which antimalarial drug?
14. Doxycycline, when used for malaria prophylaxis, must be continued for how long after leaving the endemic area?
15. The combination of sulfadoxine and pyrimethamine (Fansidar) acts synergistically by inhibiting sequential steps in which metabolic pathway?
16. Which of the following is NOT an Artemisinin Combination Therapy (ACT)?
17. A significant cardiac adverse effect associated with certain antimalarials like quinine, chloroquine, and lumefantrine is:
18. The term ‘causal prophylaxis’ refers to drugs that act on which stage of the parasite life cycle?
19. Which drug is specifically added to a regimen for P. vivax to prevent relapse from dormant liver stages?
20. The mechanism of action of artemisinin and its derivatives involves the generation of carbon-centered free radicals through the cleavage of an:
21. Which antimalarial drug’s absorption is significantly enhanced when taken with a high-fat meal?
22. Proguanil is a prodrug that is converted in the body to its active metabolite, which is:
23. Resistance of P. falciparum to chloroquine is primarily mediated by mutations in which gene?
24. A patient being treated with quinine for severe malaria develops hypoglycemia. This is due to quinine’s ability to:
25. Tafenoquine, a newer 8-aminoquinoline, offers an advantage over primaquine for radical cure due to its:
