Anti-Leprosy Drugs MCQ Quiz | Chemotherapy

Welcome to this specialized quiz on Anti-Leprosy Drugs, a critical topic in Chemotherapy for MBBS students. This quiz is designed to test your understanding of the pharmacological principles, drug classifications, mechanisms of action, and clinical applications of medications used to treat leprosy. You will encounter 25 multiple-choice questions covering key areas such as Multi-Drug Therapy (MDT) regimens for paucibacillary and multibacillary leprosy, the roles of Dapsone, Rifampicin, and Clofazimine, their adverse effects, and the management of lepra reactions. This assessment will help you consolidate your knowledge and prepare for your examinations. After submitting your answers, you can review your score and download a PDF of all questions with the correct answers for future reference.

1. Which anti-leprosy drug is known to cause a reddish-orange discoloration of urine, sweat, and tears?

2. What is the primary mechanism of action of Dapsone?

3. Which anti-leprosy drug has significant anti-inflammatory properties, making it useful in managing Type 2 lepra reactions (ENL)?

4. According to WHO guidelines, what is the standard duration of Multi-Drug Therapy (MDT) for Paucibacillary (PB) leprosy?

5. What is the standard duration of MDT for Multibacillary (MB) leprosy?

6. A potentially fatal adverse effect of Dapsone, particularly in patients with G6PD deficiency, is:

7. Which anti-leprosy drug is a potent inducer of hepatic microsomal enzymes (Cytochrome P450), leading to numerous drug interactions?

8. A patient on MDT for MB leprosy develops a reddish-brown to blackish discoloration of the skin. Which drug is most likely responsible?

9. Type 1 lepra reaction (reversal reaction), a delayed-type hypersensitivity reaction, is primarily treated with which class of drugs?

10. The drug of choice for managing severe Type 2 lepra reaction (Erythema Nodosum Leprosum – ENL), especially if corticosteroids are contraindicated or ineffective, is:

11. The potent bactericidal activity of Rifampicin against M. leprae is due to the inhibition of:

12. Dapsone is a diamino-diphenyl-sulfone, structurally related to which class of antimicrobial agents?

13. The single-dose ROM therapy for single-lesion PB leprosy consists of:

14. The main rationale for using Multi-Drug Therapy (MDT) in leprosy is to:

15. Chemoprophylaxis for household contacts of leprosy patients can be provided with a single dose of which drug?

16. Which of the following is a second-line fluoroquinolone antibiotic used in alternative regimens for leprosy, especially in cases of resistance?

17. Clofazimine is classified as a:

18. Which drug is absolutely contraindicated in pregnancy due to its severe teratogenic effects, particularly phocomelia?

19. Dapsone hypersensitivity syndrome is a severe idiosyncratic reaction characterized by:

20. In the standard MB-MDT regimen, how are the drugs typically administered?

21. Minocycline, a second-line anti-leprosy drug, belongs to which class of antibiotics?

22. Which of these anti-leprosy drugs has the longest half-life, allowing it to be stored in reticuloendothelial cells and fat for extended periods?

23. During a reversal reaction (Type 1), what should be the approach to the standard MDT?

24. The bactericidal index (BI) in leprosy is a measure of:

25. Which one of the following is NOT a component of the standard WHO-MDT regimen for Paucibacillary (PB) leprosy?

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