Adrenergic Drugs | Medicinal Chemistry | GPAT Mock Test

1. Which amino acid serves as the primary precursor for the biosynthesis of catecholamines like norepinephrine and epinephrine?

2. The rate-limiting step in the synthesis of catecholamines is catalyzed by which enzyme?

3. Clonidine acts as an antihypertensive agent primarily through which mechanism?

4. Which of the following is a selective beta-2 adrenergic agonist commonly used in the treatment of asthma?

5. Prazosin is a selective antagonist for which adrenergic receptor, making it useful in treating hypertension and benign prostatic hyperplasia (BPH)?

6. From a Structure-Activity Relationship (SAR) perspective, what structural feature generally confers beta-2 selectivity in adrenergic agonists?

7. Which of the following is an irreversible, non-selective alpha-adrenergic antagonist?

8. The metabolism of catecholamines in the synaptic cleft and neuronal cytoplasm is primarily carried out by which two enzymes?

9. Phenylephrine is a direct-acting adrenergic agonist that is selective for:

10. The aryloxypropanolamine structure is characteristic of which class of adrenergic drugs?

11. Which neurotransmitter is the principal catecholamine released from the adrenal medulla?

12. Labetalol and Carvedilol are unique beta-blockers because they also possess antagonist activity at which other receptor?

13. Which of the following drugs is a selective alpha-2 antagonist, sometimes used as an antidote for clonidine overdose?

14. What is the primary mechanism of action of indirectly acting sympathomimetic amines like amphetamine?

15. Metoprolol and Atenolol are considered “cardioselective” because they show relative selectivity for which receptor?

16. The “first-dose phenomenon,” characterized by postural hypotension, is a notable side effect associated with which class of drugs?

17. Dobutamine is a synthetic catecholamine primarily used in acute heart failure due to its relatively selective agonist activity at:

18. Reserpine depletes catecholamines from nerve endings by which mechanism?

19. The chemical modification of the catechol moiety in adrenergic agonists (e.g., in Salbutamol) serves what primary purpose?

20. Which of the following beta-blockers also possesses intrinsic sympathomimetic activity (ISA), meaning it is a partial agonist?

21. Imidazoline ring is a key structural feature present in which of the following adrenergic drugs?

22. Cocaine potentiates the effects of norepinephrine by:

23. In the SAR of phenylethylamines, the presence of a hydroxyl group on the beta-carbon is essential for:

24. What is the effect of presynaptic alpha-2 receptor activation?

25. Prazosin, Terazosin, and Doxazosin belong to which chemical class of selective alpha-1 antagonists?