Signs of coordinates MCQs With Answer is a focused collection designed for B. Pharm students to master Cartesian and spatial coordinate concepts used in plotting drug concentration–time profiles, dose-response curves, and lab data interpretation. This introduction clarifies quadrant sign conventions, axis reflections, coordinate transformations, and 3D octant identification while relating them to pharmacokinetics and pharmacodynamics graphing. Clear explanations of sign changes during rotations, translations, and reflections help students interpret slopes, midpoints, and distances in clinical and laboratory contexts. These targeted MCQs reinforce mathematical precision essential for accurate data visualization and calculation in pharmaceutical practice. Now let’s test your knowledge with 50 MCQs on this topic.
Q1. What are the signs of x and y coordinates in the first quadrant?
- Negative x, positive y
- Positive x, positive y
- Negative x, negative y
- Positive x, negative y
Correct Answer: Positive x, positive y
Q2. If a point lies in the second quadrant, what are the signs of (x, y)?
- Positive x, positive y
- Negative x, positive y
- Negative x, negative y
- Positive x, negative y
Correct Answer: Negative x, positive y
Q3. Coordinates (−3, −5) are located in which quadrant?
- First quadrant
- Second quadrant
- Third quadrant
- Fourth quadrant
Correct Answer: Third quadrant
Q4. A point lies on the positive x-axis. Which is true about its coordinates?
- x = 0 and y > 0
- x > 0 and y = 0
- x < 0 and y = 0
- x = 0 and y < 0
Correct Answer: x > 0 and y = 0
Q5. Which transformation changes (x, y) to (−x, y)?
- Reflection across the x-axis
- Reflection across the y-axis
- Rotation by 90° counterclockwise
- Translation right by x units
Correct Answer: Reflection across the y-axis
Q6. A 90° counterclockwise rotation of (x, y) yields which coordinates?
- (y, −x)
- (−y, x)
- (−x, −y)
- (x, y)
Correct Answer: (−y, x)
Q7. What are the coordinates after a 180° rotation of (2, −4)?
- (−2, 4)
- (2, 4)
- (−2, −4)
- (4, −2)
Correct Answer: (−2, 4)
Q8. Which quadrant contains points with x > 0 and y < 0?
- First quadrant
- Second quadrant
- Third quadrant
- Fourth quadrant
Correct Answer: Fourth quadrant
Q9. The midpoint of points (2, 6) and (8, 4) is:
- (5, 5)
- (10, 10)
- (−3, −1)
- (4, 6)
Correct Answer: (5, 5)
Q10. Distance between (1, 2) and (4, 6) equals:
- 3
- 5
- 4
- sqrt(13)
Correct Answer: 5
Q11. If a line between two concentration-time points has a negative slope, what does the sign indicate?
- Concentration is increasing over time
- Concentration is decreasing over time
- Time is negative
- No change in concentration
Correct Answer: Concentration is decreasing over time
Q12. What is the slope of the line through (2, 3) and (5, 11)?
- 8/3
- 3/8
- −8/3
- 4
Correct Answer: 8/3
Q13. Reflection of (x, y) across the x-axis results in:
- (x, −y)
- (−x, y)
- (y, x)
- (−y, −x)
Correct Answer: (x, −y)
Q14. Which coordinate lies on both axes?
- (0, 0)
- (1, 0)
- (0, 2)
- (−1, 1)
Correct Answer: (0, 0)
Q15. If a pharmacokinetic profile is mirrored across the y-axis, the point (3, 50) becomes:
- (−3, 50)
- (3, −50)
- (−3, −50)
- (50, 3)
Correct Answer: (−3, 50)
Q16. In 3D coordinates (x, y, z), what signs define the first octant?
- x > 0, y > 0, z > 0
- x < 0, y > 0, z > 0
- x < 0, y < 0, z < 0
- x > 0, y < 0, z > 0
Correct Answer: x > 0, y > 0, z > 0
Q17. Which operation converts (x, y) to (x + a, y + b)?
- Rotation
- Reflection
- Translation
- Scaling
Correct Answer: Translation
Q18. The point (0, −7) lies on which axis?
- x-axis
- y-axis
- Both axes
- Neither axis
Correct Answer: y-axis
Q19. Which of the following changes the sign of both coordinates?
- Translation by (1, 1)
- 90° rotation
- 180° rotation
- Reflection across y = x
Correct Answer: 180° rotation
Q20. If vector from A to B is (−4, 3), what does a negative x-component indicate?
- Movement in positive x-direction
- Movement in negative x-direction
- No movement in x-direction
- Movement parallel to y-axis
Correct Answer: Movement in negative x-direction
Q21. Which coordinate sign pattern corresponds to a point left of the y-axis and above the x-axis?
- (+, +)
- (−, +)
- (−, −)
- (+, −)
Correct Answer: (−, +)
Q22. A drug concentration point changes from (2, 5) to (2, −5). What transformation occurred?
- Reflection across y-axis
- Reflection across x-axis
- Rotation by 90°
- Translation down by 10 units
Correct Answer: Reflection across x-axis
Q23. Which of the following gives the midpoint formula for (x1, y1) and (x2, y2)?
- ((x1 + x2)/2, (y1 + y2)/2)
- ((x1 − x2)/2, (y1 − y2)/2)
- ((x1 * x2)/2, (y1 * y2)/2)
- ((x1^2 + x2^2)/2, (y1^2 + y2^2)/2)
Correct Answer: ((x1 + x2)/2, (y1 + y2)/2)
Q24. Which quadrant contains points with both coordinates negative?
- First quadrant
- Second quadrant
- Third quadrant
- Fourth quadrant
Correct Answer: Third quadrant
Q25. For polar coordinates, a negative radius r indicates:
- A point on the opposite ray with positive radius
- No defined point
- Point on the positive x-axis only
- Radius mirrored about origin only
Correct Answer: A point on the opposite ray with positive radius
Q26. Which coordinate transformation represents reflection across the line y = x?
- (x, y) → (−x, −y)
- (x, y) → (y, x)
- (x, y) → (x, −y)
- (x, y) → (−y, −x)
Correct Answer: (x, y) → (y, x)
Q27. What is the sign of the product x*y in the second quadrant?
- Positive
- Negative
- Zero
- Undefined
Correct Answer: Negative
Q28. Which of the following is true for point (−6, 0)?
- It lies on the positive y-axis
- It lies on the negative x-axis
- It is in the fourth quadrant
- Both coordinates are positive
Correct Answer: It lies on the negative x-axis
Q29. If a concentration profile is rotated 90° clockwise, (x, y) becomes:
- (y, −x)
- (−y, x)
- (x, y)
- (−x, −y)
Correct Answer: (y, −x)
Q30. A point with coordinates (0, 4) has which x sign?
- Positive
- Negative
- Zero
- Undefined
Correct Answer: Zero
Q31. Which of the following correctly identifies the change when reflecting (3, −2) across the y-axis?
- (3, −2) → (−3, −2)
- (3, −2) → (3, 2)
- (3, −2) → (−3, 2)
- (3, −2) → (2, 3)
Correct Answer: (3, −2) → (−3, −2)
Q32. The slope sign between (−1, 2) and (3, −6) is:
- Positive
- Negative
- Zero
- Undefined
Correct Answer: Negative
Q33. In pharmacology plotting, converting a point (time, concentration) to (−time, concentration) corresponds to:
- Forward time translation
- Time reversal (mirror across y-axis)
- Concentration inversion
- Scaling concentration
Correct Answer: Time reversal (mirror across y-axis)
Q34. Which coordinate pair is symmetric to (4, 7) with respect to origin?
- (4, −7)
- (−4, −7)
- (−4, 7)
- (7, 4)
Correct Answer: (−4, −7)
Q35. Point (−2, 5) reflected across y = x becomes:
- (5, −2)
- (−5, 2)
- (2, −5)
- (5, −2)
Correct Answer: (5, −2)
Q36. If a point moves from quadrant II to quadrant IV, which coordinate signs changed?
- x sign changed, y sign changed
- x sign same, y sign changed
- x sign changed, y sign same
- Neither sign changed
Correct Answer: x sign changed, y sign changed
Q37. Which statement is true for coordinates (x, y) and (−x, y)?
- They are reflections across the x-axis
- They are reflections across the y-axis
- They are reflections across the origin
- They are identical points
Correct Answer: They are reflections across the y-axis
Q38. For 3D point (−3, 2, −1), which octant is it in assuming standard numbering?
- First octant
- An octant with mixed signs (−, +, −)
- Octant where all are positive
- On an axis
Correct Answer: An octant with mixed signs (−, +, −)
Q39. When plotting a declining drug concentration, the tangent slope at a point is negative. What does slope sign imply about instantaneous rate?
- Instantaneous rate is increasing
- Instantaneous rate is decreasing (negative)
- Instantaneous rate is zero
- Instantaneous rate is undefined
Correct Answer: Instantaneous rate is decreasing (negative)
Q40. What happens to (x, y) under reflection across the line y = −x?
- (x, y) → (y, x)
- (x, y) → (−y, −x)
- (x, y) → (−x, y)
- (x, y) → (x, −y)
Correct Answer: (x, y) → (−y, −x)
Q41. Slope sign between points (0, 5) and (5, 0) is:
- Positive 1
- Negative 1
- Zero
- Undefined
Correct Answer: Negative 1
Q42. If concentration C(t) = C0 e^(−kt), the exponent sign (−k) indicates:
- Exponential growth
- Exponential decay
- Oscillation
- Linear increase
Correct Answer: Exponential decay
Q43. Which coordinates represent a point reflected across the origin from (7, −3)?
- (7, 3)
- (−7, 3)
- (−7, 3)
- (−7, 3)
Correct Answer: (−7, 3)
Q44. The angle between vector (1, 0) and (−1, 0) gives what dot product sign?
- Positive
- Zero
- Negative
- Undefined
Correct Answer: Negative
Q45. If the x-coordinate sign is flipped while y remains same, what movement happened?
- Reflection across x-axis
- Reflection across y-axis
- Rotation by 180°
- Translation along y
Correct Answer: Reflection across y-axis
Q46. For points (−2, −3) and (4, 5), the line connecting them has what general slope sign?
- Positive
- Negative
- Zero
- Undefined
Correct Answer: Positive
Q47. Which coordinate has opposite signs for x and y?
- (3, 4)
- (−3, 4)
- (−3, −4)
- (0, 0)
Correct Answer: (−3, 4)
Q48. The transformation (x, y) → (x, y) + (−2, 0) is equivalent to:
- Translation left by 2 units
- Translation right by 2 units
- Reflection across y-axis
- Rotation by 180°
Correct Answer: Translation left by 2 units
Q49. If two points have coordinates with product of x-components negative, what does that imply about their x-positions?
- Both are positive
- Both are negative
- They lie on opposite sides of y-axis
- Both lie on y-axis
Correct Answer: They lie on opposite sides of y-axis
Q50. Which of the following best links coordinate sign knowledge to B. Pharm practice?
- Understanding quadrant signs helps interpret and transform pharmacokinetic graphs and data correctly
- Coordinate signs are irrelevant to pharmacology
- Only chemistry uses coordinate signs
- Signs of coordinates only matter in pure mathematics exams
Correct Answer: Understanding quadrant signs helps interpret and transform pharmacokinetic graphs and data correctly

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.
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