About

This information provides clinical context for the Tezspire (tezepelumab) Dosing Calculator. The tool is designed to assist healthcare professionals in scheduling doses according to the approved interval, helping to streamline treatment planning and support patient adherence.

Outputs

After entering a start date, the calculator provides the following key information based on the standard dosing regimen:

  • Next Dose Due Date: The precise date for the next administration, calculated at 28 days (4 weeks) from the entered date.
  • Dosing Parameters: A summary of the recommended dose, including:
    210 mg Subcutaneous Every 4 weeks
  • Full Dosing Schedule: An option to generate a list of the next six consecutive dose dates to aid in long-term planning.
  • Calendar Integration: A feature to download an ICS file to add the next dose reminder directly to a digital calendar.

How to Use

To determine the next dose date for Tezspire, follow this simple procedure:

  • Select the Start Date: Use the date picker to input the date of the patient’s most recent dose or the planned date for their first dose.
  • Review the Results: The calculator will automatically display the date for the next scheduled dose. No further calculation is needed.
  • Reset if Necessary: Use the “Reset” button to clear the input and output fields to start a new calculation.

Dosing Overview

The recommended dosage of Tezspire for adults and pediatric patients aged 12 years and older with severe asthma is 210 mg administered by subcutaneous injection every 4 weeks. The dosage is not dependent on patient weight.

Switching

There is no specific guidance on switching from other biologics to Tezspire. Such decisions should be based on clinical judgment. When initiating Tezspire, it is not recommended to discontinue systemic or inhaled corticosteroids abruptly. Any reduction in corticosteroid dose should be gradual and performed under the direct supervision of a physician.

Missed Dose

If a patient misses a scheduled dose of Tezspire, the following guidance applies:

  • Administer the missed dose as soon as possible.
  • After administering the missed dose, the patient should resume their regular dosing schedule on the usual day of administration.
  • If the next regularly scheduled dose is already due, administer it as planned without giving the missed dose. Do not administer a double dose.

Safety Alerts

Tezspire is contraindicated in patients with a known hypersensitivity to tezepelumab-ekko or its excipients. Healthcare providers should be aware of the following:

  • Hypersensitivity Reactions: Anaphylaxis has been reported. These reactions can occur hours after administration. Monitor patients and have appropriate medical support available.
  • Acute Asthma Symptoms: Tezspire should not be used to treat acute asthma symptoms, acute exacerbations, or acute bronchospasm.
  • Risk of Parasitic (Helminth) Infection: It is unknown if Tezspire will influence a patient’s response against helminth infections. Treat patients with a pre-existing helminth infection before initiating therapy.

FAQ

1. How does the calculator determine the next dose date?

The calculator adds exactly 28 days (4 weeks) to the date you provide, in line with the official prescribing information for Tezspire.

2. Does the calculator adjust the dose for patient weight or age?

No. The recommended Tezspire dose is 210 mg every 4 weeks for all patients aged 12 years and older, regardless of body weight.

3. What should I do if a patient administers a dose a few days late?

Administer the dose as soon as it’s remembered. The patient can then resume their original schedule. For example, if doses are normally on a Tuesday and a late dose is given on a Friday, the next dose should still be on the originally scheduled Tuesday 4 weeks later.

4. How long before administration should Tezspire be removed from the refrigerator?

The pre-filled pen or syringe should be left at room temperature for at least 60 minutes before injection to ensure patient comfort and proper administration.

5. Can the injection site be the same for every dose?

No, injection sites should be rotated with each dose. Recommended sites are the thigh, abdomen (at least 2 inches away from the navel), or the upper arm (if administered by a caregiver).

6. How many future doses does the “Generate Full Schedule” feature show?

The tool generates a schedule for the next six consecutive doses, providing a six-month outlook for treatment planning.

7. What information is included in the calendar event download?

The downloaded .ics file creates a one-hour calendar event titled “Tezspire Dose Due” on the calculated next dose date, serving as a simple reminder.

8. Is this calculator a substitute for the official Prescribing Information?

Absolutely not. This tool is for informational and scheduling convenience only. All clinical decisions must be made in accordance with the full, official Prescribing Information.

9. Can patients self-administer Tezspire?

After proper training in subcutaneous injection technique, a patient may self-inject Tezspire or a caregiver may administer it if a healthcare provider determines it is appropriate.

References

  • TEZSPIRE® (tezepelumab-ekko) injection, for subcutaneous use. Prescribing Information. AstraZeneca; 2023. Available from: FDA.gov
  • Tezspire: EPAR – Product Information. European Medicines Agency (EMA). Available from: ema.europa.eu
  • Tezspire HCP Official Website. Amgen Inc. and AstraZeneca. Available from: tezspirehcp.com
  • Corren J, Parnes JR, Wang L, et al. Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017;377(10):936-946. doi:10.1056/NEJMoa1704064. Available from: nejm.org
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