About This Tool

This Siliq (brodalumab) Dosing Calculator is designed to help healthcare professionals understand the dosing schedule based on the Prescribing Information. It provides a visual and list-based timeline for the induction and maintenance phases of treatment for moderate-to-severe plaque psoriasis.

Outputs Explained

Upon entering a treatment start date, the calculator generates two key outputs:

• Schedule List: A comprehensive table detailing each dose number, the corresponding treatment week (e.g., Week 0, Week 1, Week 2, Week 4), and the exact calendar date for administration.
• Schedule Calendar: A series of monthly calendars that visually highlight the upcoming injection dates, typically for the next four months. Induction doses are specially marked to distinguish them from maintenance doses.

How to Use the Calculator

The calculator requires a single piece of information to generate the full dosing schedule:

Treatment Start Date (Week 0): Using the date picker, select the day the patient will receive their first 210 mg dose of Siliq. The tool defaults to the current date for convenience. After selecting the date, click “Calculate Schedule” to view the results.

Dosing Overview

The dosing for Siliq is divided into an initial induction phase followed by a regular maintenance phase. The calculator automates this schedule based on the FDA-approved regimen.

• Induction Dosing: The patient receives a 210 mg subcutaneous injection at Week 0, Week 1, and Week 2. This initial period is designed to establish therapeutic levels of the medication quickly.
• Maintenance Dosing: Following the induction phase, the patient receives a 210 mg subcutaneous injection every 2 weeks, starting at Week 4.

Switching Therapies

When switching a patient from another systemic therapy or biologic to Siliq, healthcare providers should use their clinical judgment to determine the appropriate timing for the first dose. There are no specific washout periods mandated in the prescribing information, but the patient’s clinical state, the half-life of the previous drug, and risk of disease flare should be considered. Always consult the full Prescribing Information for both medications when planning a switch.

Missed Dose Protocol

According to the Siliq Prescribing Information, if a patient misses a dose, they should be instructed to inject their dose as soon as they remember. After that, they should resume their regular dosing schedule. For example, if a dose was missed on a Monday and taken on a Wednesday, the next dose should still be administered on the originally scheduled Monday two weeks later.

Safety Alerts

Frequently Asked Questions (FAQ)

What is the induction phase for Siliq?

The induction phase consists of three 210 mg injections administered one week apart, at Week 0, Week 1, and Week 2.

How often is the Siliq maintenance dose administered?

After the induction phase, the maintenance dose of 210 mg is administered every two weeks.

Does the calculator adjust the dose based on patient weight?

No. The recommended dose for Siliq is 210 mg for all adult patients, regardless of weight. The calculator uses this fixed dose for its schedule.

Why does the calendar only show the next four months?

The calendar view is designed to provide a clear, near-term visual of the upcoming dosing schedule. The full, long-term schedule is available in the “Schedule List” table, which typically projects for about one year.

Can I print the dosing schedule?

Yes, you can use your browser’s print function (Ctrl+P or Cmd+P) to print the entire page, including the generated schedule, for patient records or handouts.

What is the SILIQ REMS Program?

It is a mandatory safety program required by the FDA to manage the known risk of suicidal ideation and behavior. Prescribers, pharmacies, and patients must enroll in the program to prescribe, dispense, or receive Siliq.

Is this calculator a substitute for medical advice?

No. This tool is for educational purposes only and is intended to supplement, not replace, the clinical judgment of a qualified healthcare professional. Always refer to the full Prescribing Information.

Can this calculator be used for conditions other than plaque psoriasis?

No. This calculator is based on the approved dosing for moderate-to-severe plaque psoriasis in adults and should not be used for any other indication.