Introduction
Strategies to eliminate errors and bias in MCQs is a practical guide for M.Pharm students preparing to design, validate, and analyze multiple-choice questions in research methodology and assessments. This blog emphasizes evidence-based item-writing principles, quality-control processes such as blueprinting and peer review, and psychometric techniques (item difficulty, discrimination, point-biserial, KR-20/Cronbach’s alpha, and DIF analysis) to detect biased or flawed items. It outlines operational steps—pilot testing, distractor analysis, item revision, translation validation, and elimination of common cueing practices—to enhance validity and reliability. The goal is to equip students with actionable strategies to create fair, defensible MCQs that accurately assess higher-order pharmacy competencies.
Q1. Which practice most directly reduces construct-irrelevant variance and improves the validity of an MCQ exam?
- Blueprinting items to the specified learning objectives and weighting
- Using longer stems to include more background details
- Including “All of the above” to increase option variety
- Mixing item formats (true/false with MCQs) randomly
Correct Answer: Blueprinting items to the specified learning objectives and weighting
Q2. Which stem characteristic is recommended to avoid ambiguity and reduce error in MCQs?
- Complex negative phrasing to test careful reading
- Vague terms like “often” or “rarely” to allow interpretation
- Presenting a single, clearly stated problem with all necessary data
- Including irrelevant clinical vignettes to increase length
Correct Answer: Presenting a single, clearly stated problem with all necessary data
Q3. What is the most appropriate action when a distractor is chosen by fewer than 5% of examinees?
- Keep the distractor because rare selection shows discriminating power
- Revise or replace the distractor to improve plausibility
- Mark the item as high-quality without changes
- Change the key to that distractor to increase difficulty
Correct Answer: Revise or replace the distractor to improve plausibility
Q4. Which statistic is used to measure the internal consistency of a set of dichotomous MCQs?
- Kuder-Richardson Formula 20 (KR-20)
- Spearman’s rank correlation
- Cronbach’s alpha is invalid for dichotomous items
- Mantel-Haenszel common odds ratio
Correct Answer: Kuder-Richardson Formula 20 (KR-20)
Q5. An item has a difficulty index (p-value) of 0.92. What does this indicate and what action is recommended?
- The item is very easy; consider increasing difficulty or removing it
- The item is very difficult; provide hints in the stem
- The item has ideal difficulty; keep it unchanged
- The item discriminates well and should be duplicated
Correct Answer: The item is very easy; consider increasing difficulty or removing it
Q6. Which metric best identifies items that distinguish high-performing from low-performing candidates?
- Discrimination index (point-biserial or DI)
- Difficulty index alone
- Number of words in the stem
- Test administration time
Correct Answer: Discrimination index (point-biserial or DI)
Q7. Which practice helps eliminate cultural or language bias in translated MCQs?
- Back-translation and review by bilingual subject experts
- Literal one-step translation without review
- Use of idioms that are common in the source language
- Replacing clinical terms with local slang
Correct Answer: Back-translation and review by bilingual subject experts
Q8. What is a recommended guideline regarding option length and format to minimize cueing?
- Keep options similar in length, grammar, and complexity
- Ensure the correct option is always the longest
- Vary punctuation in options to signal the key
- Make implausible distractors obviously different in style
Correct Answer: Keep options similar in length, grammar, and complexity
Q9. Which statistical method is commonly used to detect differential item functioning (DIF) and potential bias between groups?
- Mantel-Haenszel procedure
- ANOVA on total test scores only
- Factor analysis without group comparison
- Chi-square test of option lengths
Correct Answer: Mantel-Haenszel procedure
Q10. Why is avoiding negative phrasing in stems (e.g., “Which is NOT”) usually recommended?
- Negative phrasing increases cognitive load and introduces avoidable errors
- Negative stems are always more valid and should be used often
- They reduce the number of plausible distractors
- They automatically increase item difficulty appropriately
Correct Answer: Negative phrasing increases cognitive load and introduces avoidable errors
Q11. Which item-writing practice reduces the risk of cueing the correct answer?
- Avoiding absolute terms and unintentional grammatical cues
- Using identical grammatical endings only for the correct option
- Placing the key always in the same option position
- Including “None of the above” as a frequent option
Correct Answer: Avoiding absolute terms and unintentional grammatical cues
Q12. Which post-test analysis step directly informs which items should be revised or discarded?
- Item analysis including difficulty, discrimination, and distractor functioning
- Counting the number of words in each item
- Recording average time spent per item without further analysis
- Comparing item font sizes across papers
Correct Answer: Item analysis including difficulty, discrimination, and distractor functioning
Q13. What is the typical threshold for point-biserial correlation below which an item is considered poor?
- Less than 0.20
- Greater than 0.50
- Exactly 0.30 is always poor
- Negative values are always ideal
Correct Answer: Less than 0.20
Q14. Which strategy helps reduce guessing effects and better reflect true knowledge on MCQs?
- Use well-constructed plausible distractors and consider formula scoring cautiously
- Provide only two options per item to simplify guessing
- Reward random guessing by giving partial credit to all responses
- Use identical distractors to confuse the examinee
Correct Answer: Use well-constructed plausible distractors and consider formula scoring cautiously
Q15. Which guideline improves fairness when combining items from different exam forms or administrations?
- Equating or using anchor items to adjust for form difficulty
- Randomly assigning different time limits per form
- Reordering items alphabetically by stem
- Allowing each form to have unique content without tracking
Correct Answer: Equating or using anchor items to adjust for form difficulty
Q16. Why is peer review and expert panel review important before finalizing MCQs?
- They identify content errors, bias, ambiguity, and ensure curricular alignment
- Peer review guarantees all items will have equal difficulty
- Expert panels always prefer longer stems and more distractors
- They primarily increase the number of test items for length
Correct Answer: They identify content errors, bias, ambiguity, and ensure curricular alignment
Q17. Which practice helps ensure higher-order cognitive skills are assessed rather than rote recall?
- Design clinical vignettes requiring application, analysis, or synthesis
- Focus exclusively on single-fact recall items
- Use true/false items instead of scenario-based MCQs
- Make all stems purely definitional without context
Correct Answer: Design clinical vignettes requiring application, analysis, or synthesis
Q18. If Cronbach’s alpha for an MCQ exam is 0.58, what is the appropriate interpretation and next step?
- Internal consistency is low; perform item analysis and revise or remove poor items
- Alpha of 0.58 indicates excellent reliability; keep exam unchanged
- Sample size must be reduced to increase alpha automatically
- Alpha below 0.60 means the test is biased and should be discarded entirely
Correct Answer: Internal consistency is low; perform item analysis and revise or remove poor items
Q19. Which option best describes a “single best answer” (SBA) MCQ and why is it preferred?
- One clearly superior option among plausible distractors; reduces ambiguity and measures application
- Any option can be accepted if examinee explains; increases subjectivity
- Two or more equally correct answers to increase complexity
- The option with the longest wording is chosen as best
Correct Answer: One clearly superior option among plausible distractors; reduces ambiguity and measures application
Q20. What quality-control practice should be done routinely after each examination to maintain a high-quality item bank?
- Conduct item-level psychometric analysis, document revisions, and update the item bank
- Archive answer sheets without analysis for future use
- Reuse all items unchanged to maintain historical comparability
- Discard items that performed well to reduce test length
Correct Answer: Conduct item-level psychometric analysis, document revisions, and update the item bank

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.
Mail- Sachin@pharmacyfreak.com

