GI Pharmacology | Pharmacology | GPAT Mock Test

1. Which of the following is an example of a systemic antacid that can cause metabolic alkalosis upon chronic use?

2. Omeprazole exerts its anti-secretory effect by which of the following mechanisms?

3. Which H2-receptor antagonist is a potent inhibitor of cytochrome P450 enzymes and is known to cause gynecomastia?

4. Ondansetron is a highly effective antiemetic, especially for chemotherapy-induced nausea and vomiting. It acts by blocking:

5. Which of the following drugs is a bulk-forming laxative?

6. Loperamide is an effective antidiarrheal agent that is a synthetic opioid. Why does it lack central analgesic effects at therapeutic doses?

7. The mechanism of action of Sucralfate in healing peptic ulcers is:

8. Orlistat is an anti-obesity drug that functions by:

9. Which drug is a prostaglandin E1 analog used to prevent NSAID-induced gastric ulcers and is absolutely contraindicated in pregnancy?

10. Metoclopramide is a prokinetic agent that also has antiemetic properties. Its prokinetic effect is mediated through:

11. Simethicone is classified as a carminative and acts by:

12. The drug of choice for preventing motion sickness, which acts as a muscarinic receptor antagonist, is:

13. Which of the following is a stool softener that acts as an anionic surfactant?

14. Aprepitant is an antiemetic used for delayed chemotherapy-induced nausea and vomiting. It acts by blocking which receptors in the brain?

15. Which antihistaminic drug, primarily a 5-HT2 antagonist, is also used as an appetite stimulant?

16. Pancrelipase is a digestant used in conditions like pancreatitis. It is a mixture of:

17. A common side effect associated with aluminum-containing antacids is:

18. The standard first-line triple therapy for H. pylori eradication typically includes a proton pump inhibitor and which two antibiotics?

19. Lactulose is an osmotic laxative that is also used in the management of:

20. Domperidone is preferred over Metoclopramide as a prokinetic agent in some cases because it:

21. A centrally acting emetic that is a potent dopamine agonist, administered parenterally for poisoning, is:

22. Bismuth subsalicylate is used for traveler’s diarrhea. A common, harmless side effect is:

23. Proton pump inhibitors like Pantoprazole are administered as enteric-coated tablets because they are:

24. Co-administration of antacids containing divalent or trivalent cations (Mg2+, Al3+, Ca2+) significantly reduces the absorption of which class of antibiotics?

25. Which of the following laxatives belongs to the stimulant/irritant category?