Neuromuscular & Parkinson’s Drugs | Medicinal Chemistry | GPAT Mock Test

1. Which of the following is an isoquinoline derivative non-depolarizing neuromuscular blocker that undergoes Hofmann elimination?

2. The primary reason for co-administering Carbidopa with Levodopa in the treatment of Parkinson’s disease is to:

3. Dantrolene, a direct-acting muscle relaxant, exerts its effect by:

4. Which structural feature is essential for the activity of steroidal non-depolarizing neuromuscular blockers like Pancuronium?

5. Selegiline is used as an adjunct in Parkinson’s disease therapy. Its mechanism of action is:

6. A patient on Succinylcholine experiences prolonged muscle paralysis. This is most likely due to a genetic deficiency in which enzyme?

7. Which of the following drugs is a centrally acting muscle relaxant that functions as a GABA-B receptor agonist?

8. Tolcapone is a COMT inhibitor used for Parkinson’s disease. What is the major concern that limits its use compared to Entacapone?

9. The “on-off” phenomenon associated with long-term Levodopa therapy refers to:

10. Which of the following is a non-ergot dopamine agonist used in the treatment of Parkinson’s disease?

11. The chemical structure of Baclofen contains a gamma-aminobutyric acid (GABA) moiety with a substituent at which position?

12. Rocuronium has a faster onset of action compared to other steroidal neuromuscular blockers. This is primarily attributed to its:

13. Which antiviral agent was serendipitously found to have antiparkinsonian effects by enhancing dopamine release and blocking its reuptake?

14. Carisoprodol, a centrally acting muscle relaxant, is metabolized in the body to which active substance?

15. The primary mechanism of action of Tizanidine as a muscle relaxant involves:

16. In the structure of Levodopa, the catechol moiety is essential for its recognition by:

17. Which of the following statements about Succinylcholine is TRUE?

18. Entacapone differs from Tolcapone in that it:

19. Which centrally active anticholinergic drug is primarily used to treat the tremor associated with Parkinson’s disease?

20. The chemical structure of Pancuronium bromide contains:

21. What is the primary adverse effect associated with the use of Baclofen, especially upon abrupt withdrawal?

22. The ‘cheese reaction’, a hypertensive crisis, can occur when a non-selective MAO inhibitor is taken with tyramine-rich foods. This is less of a concern with Selegiline at low doses because:

23. Cisatracurium is a stereoisomer of atracurium. What is its main advantage over atracurium?

24. Which functional group in Succinylcholine makes it susceptible to rapid hydrolysis by plasma cholinesterases?

25. Apomorphine is a potent dopamine agonist used for ‘rescue’ therapy in advanced Parkinson’s disease. From a medicinal chemistry perspective, it is structurally related to: