Complexation | Physical Pharmacy | GPAT Mock Test

1. The complex formed between Iodine and Polyvinylpyrrolidone (PVP) is an example of which type of complex?

2. Job’s method, also known as the continuous variation method, is primarily used to determine the:

3. EDTA is a classic example of a chelating agent. What is the denticity of EDTA (Ethylenediaminetetraacetic acid)?

4. Cyclodextrins are widely used in pharmaceuticals to form which type of complexes, enhancing drug solubility and stability?

5. The Higuchi and Connors method is a widely used analytical technique to study complexation, based on:

6. Which of the following is NOT a primary pharmaceutical application of complexation?

7. Quinhydrone electrode functions based on the formation of which type of complex?

8. In a phase solubility diagram of a 1:1 complex (Type A_L), what does the initial linear portion of the curve represent?

9. Clathrate complexes are a type of inclusion complex where the guest molecule is entrapped within:

10. What is the main principle behind using complexation for taste masking?

11. The interaction between Benzene (electron donor) and Trinitrobenzene (electron acceptor) forms a:

12. Which analytical method is most suitable for studying complexes that exhibit a significant change in their molar absorptivity upon formation?

13. The complexation of tetracycline with metal ions like Ca²⁺, Mg²⁺, and Al³⁺ in antacids leads to:

14. Which of the following is an example of a “channel-type” inclusion complex?

15. The stability of a complex is quantitatively expressed by its:

16. Protein binding of drugs is a significant pharmaceutical phenomenon. This interaction is a form of:

17. In the classification of metal ion complexes, what distinguishes a chelate from other coordination compounds?

18. A phase solubility diagram showing an initial rise in solubility followed by a plateau and then a decrease upon further addition of ligand is classified as:

19. Which force is the primary driver for the formation of inclusion complexes with cyclodextrins in aqueous solutions?

20. The use of caffeine to increase the solubility of a poorly soluble drug like theophylline is an example of:

21. In preparing a complex by the kneading method, what is typically done?

22. Dimercaprol (BAL) is used as an antidote for heavy metal poisoning (e.g., arsenic, mercury). It functions as a:

23. From the following, which class of complexes is based on the donor-acceptor mechanism?

24. What is the “chelate effect”?

25. The Benesi-Hildebrand method is an analytical technique used to determine the stability constant and stoichiometry of a 1:1 complex, typically using data from: