Atherosclerotic Disease MCQ Quiz | Vascular (Arteries)

Welcome, MBBS students! This comprehensive quiz is designed to test your understanding of Atherosclerotic Disease, a cornerstone topic in vascular pathology. Covering everything from the initial endothelial dysfunction to the clinical manifestations and management strategies, these 25 multiple-choice questions will challenge your knowledge. This is an excellent opportunity to revise key concepts like plaque formation, risk factors, and therapeutic interventions. After submitting your answers, you’ll receive your score and see a detailed breakdown of the correct and incorrect responses. For your convenience and future study, a button will be available to download all the questions along with their correct answers in a clean PDF format. Good luck with your preparation!

1. What is the initial key event in the pathogenesis of atherosclerosis?

2. Which lipoprotein is most directly implicated in the formation of atherosclerotic plaques by accumulating in the intima?

3. “Foam cells” in an atherosclerotic plaque are primarily derived from which cell type?

4. The fibrous cap of a stable atherosclerotic plaque is primarily composed of:

5. Which of the following is considered a major non-modifiable risk factor for atherosclerosis?

6. A patient presents with intermittent leg pain during exercise that is relieved by rest. This symptom, known as intermittent claudication, is most characteristic of atherosclerosis in which arteries?

7. The rupture of an unstable atherosclerotic plaque typically leads to which acute event?

8. Which inflammatory marker is an independent predictor of risk for future cardiovascular events related to atherosclerosis?

9. Statins, a cornerstone of atherosclerosis management, primarily work by:

10. In the context of atherosclerosis, what is the primary role of high-density lipoprotein (HDL)?

11. A “fatty streak” is considered which type of lesion according to the American Heart Association (AHA) classification of atherosclerotic plaques?

12. The most common site for the development of atherosclerotic plaques in the coronary circulation is the:

13. What histological feature distinguishes a complicated plaque (AHA Type VI) from an uncomplicated atheroma?

14. What is the primary function of low-dose aspirin in the secondary prevention of atherosclerotic events?

15. How does hypertension accelerate the process of atherosclerosis?

16. The Ankle-Brachial Index (ABI) is a non-invasive diagnostic tool used to screen for atherosclerosis in which vascular bed?

17. Which of the following best describes the role of smooth muscle cells (SMCs) in plaque formation?

18. A patient is diagnosed with familial hypercholesterolemia. This genetic disorder significantly increases the risk of premature atherosclerosis due to a defect in:

19. The “response-to-injury” hypothesis of atherosclerosis posits that the process is initiated by:

20. Which component of an atherosclerotic plaque is most responsible for its thrombogenicity upon rupture?

21. In atherosclerosis of the abdominal aorta, the most common and serious complication is:

22. What is the effect of diabetes mellitus on the progression of atherosclerosis?

23. The gold standard imaging modality for visualizing the lumen of coronary arteries and assessing the severity of stenosis is:

24. A thin, unstable fibrous cap in an atherosclerotic plaque is associated with:

25. Which lifestyle modification has the most significant impact on raising HDL cholesterol levels?