1. What is the most common histological type of pancreatic cancer?
2. A 65-year-old male presents with painless, progressive jaundice and a palpable, non-tender gallbladder. This clinical finding is known as:
3. Which tumor marker is most commonly associated with pancreatic adenocarcinoma and used for monitoring disease progression?
4. Which of the following is the most significant modifiable risk factor for pancreatic cancer?
5. The standard surgical procedure for a resectable tumor in the head of the pancreas is:
6. Which genetic mutation is most frequently found in pancreatic ductal adenocarcinoma, occurring in over 90% of cases?
7. What is the initial imaging modality of choice for a patient with suspected pancreatic cancer presenting with obstructive jaundice?
8. The “double duct sign” on ERCP or MRCP is highly suggestive of a tumor in which part of the pancreas?
9. For definitive tissue diagnosis of a pancreatic mass, especially when surgery is not immediately planned, which procedure is preferred?
10. Trousseau’s sign of malignancy, sometimes seen in pancreatic cancer, refers to:
11. What is the most common site of distant metastasis for pancreatic cancer?
12. A tumor located in the body or tail of the pancreas is most likely to present with which symptom?
13. The administration of chemotherapy before surgical resection for a borderline resectable tumor is known as:
14. Which of the following is an absolute contraindication for curative surgical resection (Whipple procedure)?
15. A patient with unresectable pancreatic cancer develops severe pruritus due to obstructive jaundice. What is the most appropriate palliative intervention?
16. The sudden onset of which condition in an elderly, non-obese individual should raise suspicion for pancreatic cancer?
17. Which of these genetic syndromes is associated with an increased risk of pancreatic cancer?
18. The primary purpose of adjuvant chemotherapy (e.g., FOLFIRINOX) after surgical resection of pancreatic cancer is to:
19. Pancreatic neuroendocrine tumors (PNETs) arise from which type of cells?
20. What is the main reason for the generally poor prognosis of pancreatic cancer?
21. In a classic Whipple procedure, which of the following structures is typically NOT resected?
22. Which imaging study is the most accurate for local staging and assessing vascular involvement in pancreatic cancer?
23. Chronic pancreatitis is a significant risk factor for developing pancreatic cancer. The underlying mechanism is thought to be primarily related to:
24. What is the primary role of a PET scan in the management of pancreatic cancer?
25. For a tumor in the tail of the pancreas without vascular involvement or metastasis, the appropriate surgical treatment is:
