Precocious Puberty MCQ Quiz | Endocrinology

Welcome to this specialized quiz on Precocious Puberty, designed for MBBS students navigating the complexities of Endocrinology. This quiz will test your understanding of the pathophysiology, classification, diagnosis, and management of early pubertal onset. Covering key topics from GnRH-dependent (central) to GnRH-independent (peripheral) causes, diagnostic algorithms involving GnRH stimulation tests, bone age assessment, and imaging, this quiz serves as a vital tool for self-assessment. Challenge yourself with these 25 multiple-choice questions to reinforce your knowledge and prepare for your examinations. After submitting your answers, you can review your score and download a complete PDF of all questions with the correct answers for future reference and study. Good luck!

1. Precocious puberty is defined as the onset of secondary sexual characteristics before what age in boys?

2. Which of the following is the most common cause of central precocious puberty (CPP) in girls?

3. A GnRH stimulation test is performed on a 7-year-old girl with breast development. A pubertal response is characterized by:

4. McCune-Albright syndrome is a classic cause of peripheral precocious puberty. Its triad includes polyostotic fibrous dysplasia, café-au-lait spots, and which other feature?

5. The primary goal of treating central precocious puberty with a GnRH agonist is to:

6. A 6-year-old boy presents with pubic hair, acne, and accelerated growth but no testicular enlargement (prepubertal volume). This presentation is most suggestive of:

7. Which diagnostic tool is most crucial for assessing skeletal maturity and predicting adult height in a child with precocious puberty?

8. A 5-year-old girl has isolated breast development without any other signs of puberty. Her bone age is consistent with her chronological age. What is the most likely diagnosis?

9. Familial male-limited precocious puberty (testotoxicosis) is caused by a gain-of-function mutation in which receptor?

10. In a patient with peripheral precocious puberty due to an ovarian granulosa cell tumor, you would expect to find:

11. A hypothalamic hamartoma is a non-neoplastic, heterotopic mass that causes central precocious puberty by:

12. Which of the following conditions is characterized by isolated development of pubic and/or axillary hair before age 8 in girls or 9 in boys, without other signs of puberty?

13. In central precocious puberty, the sequence of pubertal events is typically:

14. Which of the following medications is used to treat familial male-limited precocious puberty by blocking androgen synthesis?

15. A brain MRI is most strongly indicated in which of the following scenarios?

16. What is the mechanism of action of GnRH agonists (like leuprolide) in treating central precocious puberty?

17. Untreated congenital adrenal hyperplasia (CAH), particularly the 21-hydroxylase deficiency type, leads to:

18. Exogenous exposure to which substance can cause isosexual peripheral precocious puberty in girls?

19. A key feature distinguishing central from peripheral precocious puberty in boys is:

20. The mutation in McCune-Albright syndrome affects the GNAS1 gene, leading to a constitutively active:

21. A 7-year-old girl with CPP is started on leuprolide. Which of the following is an expected, transient effect in the first 1-2 weeks of treatment?

22. Primary hypothyroidism can paradoxically cause precocious puberty, which is characterized by:

23. What finding on a pelvic ultrasound would support a diagnosis of central precocious puberty in a 6-year-old girl?

24. Which type of tumor is known to cause isosexual precocious puberty in boys by secreting hCG, which mimics LH activity?

25. The main psychosocial reason for treating precocious puberty is to: