Vaginal Discharge & Sexually Transmitted Infections MCQ Quiz | Gynaecology

1. A 24-year-old female presents with a malodorous, thin, grayish-white vaginal discharge. A “whiff” test performed by adding 10% KOH to the discharge is positive. On microscopic examination of a saline wet mount, which of the following findings would be most characteristic of her condition?

2. A 28-year-old sexually active woman is diagnosed with Chlamydia trachomatis cervicitis. What is the recommended first-line treatment for this condition in a non-pregnant patient?

3. A patient presents with a painless, indurated ulcer with a clean base on her labia. She also has non-tender inguinal lymphadenopathy. Which organism is the most likely cause?

4. A “strawberry cervix” (colpitis macularis) is a pathognomonic sign, though seen in only a minority of cases, for which of the following infections?

5. Which of the following conditions is characterized by a normal vaginal pH (typically ≤ 4.5)?

6. A 22-year-old woman is diagnosed with Pelvic Inflammatory Disease (PID). Which two organisms are most commonly implicated in causing PID?

7. What is the gold standard for diagnosing both Neisseria gonorrhoeae and Chlamydia trachomatis infections?

8. A patient is treated for primary syphilis with a single dose of intramuscular Benzathine Penicillin G. 12 hours later, she develops fever, chills, myalgia, and headache. This reaction is best described as:

9. A 30-year-old female presents with extremely painful, grouped vesicles on an erythematous base on her vulva. This clinical presentation is most typical for:

10. Fitz-Hugh-Curtis syndrome is a complication of PID characterized by perihepatitis. What is the classic clinical sign associated with this syndrome?

11. A 25-year-old pregnant woman at 14 weeks gestation is diagnosed with Trichomoniasis. What is the recommended treatment?

12. Which HPV types are most commonly associated with cervical cancer?

13. A 29-year-old male presents with a tender inguinal “groove sign” (lymphadenopathy above and below the inguinal ligament). He recently had a transient, painless genital ulcer. This presentation is characteristic of which STI?

14. A patient is diagnosed with uncomplicated urogenital gonorrhea. Due to the high rate of coinfection, empiric treatment for which other STI is typically co-administered?

15. Donovan bodies, seen as intracytoplasmic cysts in macrophages on tissue smear, are diagnostic for which condition?

16. Which of the following is NOT part of Amsel’s criteria for diagnosing Bacterial Vaginosis? (Need 3 of 4 for diagnosis)

17. A 62-year-old postmenopausal woman complains of vaginal dryness, dyspareunia, and a watery, sometimes yellowish discharge. Pelvic exam reveals a pale, thin vaginal mucosa with loss of rugae. What is the most likely diagnosis?

18. The practice of providing medication to the partner(s) of a person diagnosed with an STI without a direct medical evaluation of the partner is known as:

19. A painful genital ulcer with a friable base and purulent exudate, accompanied by tender, suppurative inguinal lymphadenopathy, is characteristic of an infection by:

20. What is the mechanism of action of Metronidazole, the drug of choice for both Bacterial Vaginosis and Trichomoniasis?

21. In a patient with PID, severe tenderness on bimanual examination, particularly with movement of the cervix, is known as:

22. Which non-treponemal test is commonly used for screening for syphilis and monitoring treatment response?

23. A 20-year-old college student presents with a thick, white, “cottage cheese-like” vaginal discharge and intense vulvar itching. A 10% KOH prep of the discharge would most likely reveal:

24. Which of the following statements about physiological vaginal discharge is TRUE?

25. What is the most significant long-term sequela of untreated Chlamydial or Gonococcal PID?