Pathophysiology of Ovary Tube Uterus Cervix Vagina MCQ Quiz | Basic Sciences

Welcome, MBBS students! This quiz is designed to test your understanding of the pathophysiology of the female reproductive system, a cornerstone of basic sciences. Covering 25 multiple-choice questions, this assessment delves into critical topics such as Polycystic Ovary Syndrome (PCOS), endometriosis, pelvic inflammatory disease (PID), and the role of HPV in cervical neoplasia. Each question challenges you to apply your knowledge of disease mechanisms, clinical presentations, and histopathological findings. After submitting your answers, you’ll receive your score and see the correct responses highlighted. For your revision, you can also download a PDF file containing all the questions and their correct answers. This is an excellent tool for self-assessment and exam preparation. Good luck!

1. A 28-year-old woman presents with hirsutism, oligomenorrhea, and infertility. Ultrasound reveals multiple small follicular cysts. Which hormonal profile is most characteristic of her condition, Polycystic Ovary Syndrome (PCOS)?

2. The most common site for an ectopic pregnancy is the:

3. A 45-year-old woman presents with cyclical pelvic pain, dysmenorrhea, and dyspareunia. A laparoscopy reveals endometrial glands and stroma located within the myometrium. What is the most likely diagnosis?

4. Which high-risk Human Papillomavirus (HPV) types are most commonly associated with the development of cervical intraepithelial neoplasia (CIN) and cervical cancer?

5. A Pap smear reveals cervical cells with nuclear enlargement, irregular nuclear membranes, and a perinuclear halo. These cellular changes are referred to as:

6. The presence of “clue cells” on a wet mount of vaginal discharge is diagnostic for:

7. A 60-year-old woman presents with postmenopausal bleeding. An endometrial biopsy reveals endometrial glands that are crowded, architecturally complex, with cytologic atypia. This condition is a direct precursor to:

8. Which of the following is the most common benign tumor of the uterus, often presenting with heavy menstrual bleeding and a feeling of pelvic pressure?

9. Pelvic Inflammatory Disease (PID) is most commonly caused by an ascending infection from which two microorganisms?

10. An ovarian cyst lined by various mature tissues including skin, hair, and teeth is best classified as a:

11. What are “chocolate cysts” of the ovary characteristic of?

12. Psammoma bodies are microscopic, calcified structures most characteristically seen in which ovarian neoplasm?

13. A patient presents with a ‘strawberry cervix’ (colpitis macularis) on speculum examination and a frothy, yellow-green vaginal discharge. This is highly suggestive of infection with:

14. Meigs syndrome is a clinical triad consisting of an ovarian fibroma, ascites, and:

15. A complete hydatidiform mole is characterized by which of the following genetic compositions?

16. The pathogenesis of endometrial hyperplasia is most closely linked to:

17. A 55-year-old woman is diagnosed with an ovarian granulosa cell tumor. Which clinical sign would be most expected?

18. Asherman’s syndrome, a cause of secondary amenorrhea and infertility, is characterized by:

19. A young woman is diagnosed with an ovarian dysgerminoma. This tumor is the ovarian counterpart of which testicular germ cell tumor and is sensitive to radiation therapy?

20. Lichen sclerosus is a chronic inflammatory condition of the vulva characterized by:

21. The most common primary malignant tumor of the vagina is:

22. Which histological feature is pathognomonic for a granulosa cell tumor of the ovary?

23. In tubo-ovarian abscess, a severe complication of PID, the primary pathological process is:

24. The transformation zone of the cervix is a common site for dysplasia and carcinoma because it is an area of:

25. Lynch syndrome (HNPCC) significantly increases a woman’s risk for which two gynecological cancers?

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