Thrombocytopenia & Thrombocytosis MCQ Quiz | Hematology

1. A 30-year-old woman presents with petechiae and mucosal bleeding. Her CBC shows a platelet count of 15,000/μL, with normal hemoglobin and WBC count. Peripheral smear shows giant platelets. Bone marrow examination is normal. What is the most likely diagnosis?

2. The classic pentad of Thrombotic Thrombocytopenic Purpura (TTP) includes microangiopathic hemolytic anemia, thrombocytopenia, fever, renal dysfunction, and which other feature?

3. A patient develops a 60% drop in platelet count 7 days after starting heparin therapy. An arterial thrombus is also noted in the leg. This clinical picture is most suggestive of:

4. The underlying pathophysiology of TTP involves a deficiency of which enzyme?

5. Which of the following is the most common cause of reactive (secondary) thrombocytosis?

6. Platelet sequestration in an enlarged spleen (hypersplenism) typically causes:

7. A 65-year-old male has a platelet count of 800,000/μL. A JAK2 V617F mutation is detected. He has a history of a transient ischemic attack. Which diagnosis is most likely?

8. Which of the following is the first-line treatment for an adult with newly diagnosed symptomatic ITP and a platelet count of 10,000/μL?

9. In a patient with Disseminated Intravascular Coagulation (DIC), which set of laboratory findings is most expected?

10. The peripheral smear finding of schistocytes is a hallmark of which condition?

11. A normal platelet count range in a healthy adult is typically:

12. Prophylactic platelet transfusion is generally considered for a non-bleeding patient with chemotherapy-induced thrombocytopenia when the platelet count falls below:

13. Bernard-Soulier syndrome is a qualitative platelet disorder characterized by a defect in which glycoprotein receptor, leading to giant platelets and thrombocytopenia?

14. Which of the following conditions is an example of thrombocytopenia due to decreased production?

15. What is the immediate and most critical management step in a patient with suspected TTP?

16. The most common genetic mutation found in Philadelphia-negative myeloproliferative neoplasms like Essential Thrombocythemia and Polycythemia Vera is:

17. A patient with cirrhosis and portal hypertension presents with a platelet count of 70,000/μL. The most likely mechanism for the thrombocytopenia is:

18. The antibodies in Type 2 HIT are directed against what complex?

19. Which of the following is a key feature that helps distinguish reactive thrombocytosis from a primary myeloproliferative neoplasm like ET?

20. In a patient with confirmed HIT and thrombosis, what is the appropriate management?

21. Wiskott-Aldrich syndrome is a rare X-linked disorder characterized by eczema, recurrent infections, and:

22. Pseudothrombocytopenia is a laboratory artifact most commonly caused by:

23. A patient with Essential Thrombocythemia and a very high platelet count (>1,500,000/μL) paradoxically develops bleeding. This is most likely due to:

24. What is the primary role of thrombopoietin (TPO)?

25. Hemolytic Uremic Syndrome (HUS), especially in children, is most commonly associated with: