Shigellosis MCQ Quiz | Infectious Diseases – Bacterial

Welcome to the Shigellosis MCQ Quiz, specifically designed for MBBS students navigating the complexities of bacterial infectious diseases. This comprehensive assessment features 25 meticulously crafted multiple-choice questions covering the essential aspects of Shigellosis. You will be tested on its microbiology, the intricate pathogenesis involving Shiga toxin, key epidemiological factors, classic clinical presentations, and serious complications like Hemolytic Uremic Syndrome (HUS). The quiz also evaluates your knowledge of modern diagnostic techniques, current antibiotic treatment guidelines, and crucial prevention strategies. This is an excellent tool for self-assessment and exam preparation. After submitting your answers, you will receive your score and a detailed review. You can also download all questions with their correct answers in a PDF file for future study.

1. Which species of Shigella is most commonly associated with epidemic dysentery and the most severe form of the disease?

2. The primary mechanism by which Shigella causes disease involves:

3. The Shiga toxin (Stx) produced by S. dysenteriae type 1 exerts its cytotoxic effect by:

4. Which of the following biochemical characteristics is typical for Shigella species?

5. What is the most common mode of transmission for Shigellosis?

6. Shigellosis is known for its high infectivity. What is the approximate infectious dose?

7. A classic presentation of shigellosis (bacillary dysentery) includes which of the following triads?

8. A 6-year-old child develops acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia one week after an episode of bloody diarrhea. Which pathogen is most strongly associated with this complication?

9. The gold standard for diagnosing Shigellosis is:

10. Which of the following is a selective and differential medium commonly used to isolate Shigella from stool samples?

11. According to current guidelines in many regions, what is the first-line antibiotic for severe shigellosis in adults?

12. How does Shigella spread from one intestinal epithelial cell to an adjacent one, evading the host immune response?

13. Post-infectious reactive arthritis (Reiter’s syndrome) is a known complication of infection with which Shigella species in HLA-B27 positive individuals?

14. Which of the following is the most effective measure for preventing the spread of shigellosis?

15. Which Shigella species is most commonly isolated in developed, industrialized countries?

16. A key finding on microscopic examination of a stool sample from a patient with bacillary dysentery is the presence of:

17. Which type of medication is generally contraindicated in patients with shigellosis as it can prolong fever and bacterial shedding?

18. The Shigella virulence protein IpaB is crucial for which step in pathogenesis?

19. Shigella species are serologically classified into four main groups (A, B, C, D) based on which antigen?

20. A major biochemical and motility difference between Shigella and enteroinvasive E. coli (EIEC) is that:

21. Where in the gastrointestinal tract does Shigella primarily initiate its invasion of the host epithelium?

22. Resistance in Shigella to antibiotics like ampicillin and trimethoprim-sulfamethoxazole is most commonly mediated by:

23. In an uncomplicated case of shigellosis in an immunocompetent adult, the illness is typically:

24. Most of the genes required for the invasion of epithelial cells by Shigella are located on:

25. The primary immune response that confers protection against subsequent infection with the same Shigella serotype is: