Schizophrenia MCQ Quiz | Medical Psychiatry

Welcome to this comprehensive multiple-choice quiz on Schizophrenia, specifically designed for MBBS students preparing for their Medical Psychiatry examinations. This quiz covers essential concepts including etiology, clinical features, diagnostic criteria, psychopathology, and management of schizophrenia. Each of the 25 questions is crafted to test your core knowledge and clinical understanding of this complex disorder. After completing the quiz, you can submit your answers to see your score, review which questions you answered correctly and incorrectly, and understand the right choices. For your revision, a “Download Answers (PDF)” button is available, allowing you to save a complete list of all questions along with their correct answers for offline study. Good luck!

1. Which of the following is considered a “positive” symptom of schizophrenia?

2. According to the dopamine hypothesis, which pathway is primarily associated with the positive symptoms of schizophrenia?

3. Which of the following is one of Schneider’s First-Rank Symptoms (FRS) of schizophrenia?

4. According to DSM-5 criteria, for a diagnosis of schizophrenia, continuous signs of the disturbance must persist for at least:

5. A patient on haloperidol develops muscle rigidity, fever, autonomic instability, and altered mental status. Which condition is most likely?

6. Which second-generation (atypical) antipsychotic is particularly known for causing agranulocytosis and requires regular blood monitoring?

7. The term “alogia” as a negative symptom of schizophrenia refers to:

8. Which of the following is the best prognostic factor in schizophrenia?

9. A patient presents with disorganized speech, disorganized behavior, and flat affect, with symptoms present for 5 months. The most appropriate diagnosis is:

10. Extrapyramidal side effects (EPS) from antipsychotics are caused by the blockade of dopamine D2 receptors in which pathway?

11. A patient with schizophrenia believes that news anchors on television are sending him special, coded messages. This is an example of:

12. Which of these antipsychotic medications has a partial D2 agonist mechanism of action?

13. Catatonic schizophrenia is primarily characterized by:

14. The lifetime prevalence of schizophrenia worldwide is approximately:

15. A patient on risperidone complains of breast enlargement and lactation. This is due to dopamine blockade in which pathway leading to hyperprolactinemia?

16. The concept of “downward drift” or “social drift” hypothesis in schizophrenia suggests that:

17. Which of the following is NOT a characteristic feature of schizoaffective disorder?

18. The most common type of hallucination experienced by patients with schizophrenia is:

19. Involuntary, repetitive, choreoathetoid movements of the mouth, lips, and tongue after long-term antipsychotic use is known as:

20. The “expressed emotion” (EE) concept in families of schizophrenic patients refers to:

21. Which neurotransmitter system, besides dopamine, is most strongly implicated in the pathophysiology of schizophrenia, particularly cognitive and negative symptoms?

22. What is the approximate concordance rate for schizophrenia in monozygotic twins?

23. A patient speaks in a sequence of unrelated or remotely related ideas, with the frame of reference often changing from one sentence to the next. This is known as:

24. Which of the following atypical antipsychotics is most associated with significant weight gain and metabolic syndrome?

25. A patient with schizophrenia maintains an awkward, rigid posture for hours and does not respond to instructions. This phenomenon is called: