Pemphigus MCQ Quiz | Vesiculobullous Disorders

Welcome, MBBS students! This quiz is designed to test your understanding of Pemphigus, a critical topic within Vesiculobullous Disorders. You will face 25 multiple-choice questions covering its pathophysiology, clinical features, diagnosis, and management. This interactive assessment will help you consolidate your knowledge on this group of rare autoimmune blistering diseases. Carefully read each question and select the best possible answer from the given options. After submitting your answers, you will receive your score, and the correct answers will be highlighted for your review. To aid your revision, an option to download all questions along with their correct answers in a PDF format is available at the end of the quiz. Good luck with your preparation!

1. The primary autoantibodies in Pemphigus Vulgaris target which of the following proteins?

2. The characteristic histological feature of pemphigus is:

3. What is the classic pattern seen on direct immunofluorescence (DIF) of perilesional skin in Pemphigus?

4. A positive Nikolsky’s sign, where gentle lateral pressure on perilesional skin causes epidermal separation, is characteristic of:

5. Which form of pemphigus is typically characterized by superficial erosions and crusted lesions on the face and upper trunk, with no mucosal involvement?

6. The rounded, acantholytic keratinocytes found in the blister fluid or on a Tzanck smear are known as:

7. The intraepidermal split in Pemphigus Vulgaris most commonly occurs at which level?

8. What is the first-line systemic therapy for moderate to severe Pemphigus Vulgaris?

9. Which of the following drugs is most commonly associated with inducing pemphigus?

10. In mucosal-dominant Pemphigus Vulgaris, autoantibodies are predominantly directed against:

11. In mucocutaneous Pemphigus Vulgaris, autoantibodies are directed against:

12. The “tombstone” pattern on histopathology of Pemphigus Vulgaris refers to:

13. Which diagnostic test is considered the gold standard for confirming a diagnosis of pemphigus?

14. Paraneoplastic pemphigus is most commonly associated with which underlying malignancy?

15. How can Pemphigus Vulgaris be differentiated from Bullous Pemphigoid based on the location of the blister?

16. Rituximab, a monoclonal antibody used for refractory pemphigus, targets which molecule on B-lymphocytes?

17. Pemphigus Foliaceus is caused by autoantibodies against which specific protein?

18. The Asboe-Hansen sign (bulla spread sign) is demonstrated by:

19. Which laboratory test can be used to quantify the levels of circulating anti-desmoglein antibodies and monitor disease activity?

20. Pemphigus Vulgaris most commonly affects individuals in which age group?

21. The bullae in Pemphigus Vulgaris are typically described as:

22. A variant of pemphigus characterized by both crusted lesions and vesicopustules, often in a seborrheic distribution, and features of lupus erythematosus is known as:

23. Indirect immunofluorescence (IIF) on a patient’s serum with pemphigus is used to detect:

24. Which immunosuppressive agent is commonly used as a steroid-sparing agent in the management of pemphigus?

25. Before the advent of corticosteroids, the prognosis for Pemphigus Vulgaris was: