1. What is the primary mechanism of action of Albendazole?
2. Praziquantel is highly effective against most trematodes and cestodes by primarily acting on:
3. Which drug is the first-line treatment for neurocysticercosis, often administered with corticosteroids?
4. The Mazzotti reaction, an intense inflammatory response to dying microfilariae, is a characteristic adverse effect of which drug?
5. Ivermectin exerts its antihelminthic effect by targeting which channels in the worm’s nerve and muscle cells?
6. What is the drug of choice for treating all species of Schistosoma (bilharzia)?
7. The preferred treatment for infections caused by *Strongyloides stercoralis* is:
8. Niclosamide is a second-line drug used primarily for the treatment of:
9. Benzimidazoles like Mebendazole and Albendazole are generally contraindicated in which condition due to their potential teratogenicity?
10. Which drug causes spastic paralysis in worms by acting as a depolarizing neuromuscular blocking agent?
11. Which drug is the cornerstone of treatment for lymphatic filariasis caused by *Wuchereria bancrofti*?
12. Long-term, high-dose therapy with Albendazole for conditions like hydatid disease requires monitoring for which potential toxicities?
13. The bioavailability of which antihelminthic drug is significantly increased when taken with a fatty meal, enhancing its systemic efficacy?
14. Which drug is effective against both the enteral (adult) and parenteral (larval) stages of *Trichinella spiralis*?
15. What is the drug of choice for treating onchocerciasis (River Blindness)?
16. Praziquantel is effective against a wide range of flukes but has poor activity against:
17. Resistance to benzimidazole drugs like albendazole is most commonly associated with a mutation in the gene encoding which protein?
18. Visceral larva migrans, caused by *Toxocara* species, is best treated with:
19. Diethylcarbamazine (DEC) is particularly effective against which stage of filarial worms?
20. Besides its antihelminthic properties, Ivermectin is also a first-line treatment for which ectoparasitic infection?
21. The rapid effect of Praziquantel on schistosomes involves damaging which part of the worm, exposing its antigens to the host immune system?
22. Which older antihelminthic drug works by causing flaccid paralysis of the worm through GABA receptor agonism, leading to its expulsion by peristalsis?
23. Medical management of hydatid disease caused by *Echinococcus granulosus* typically involves long-term therapy with:
24. A common side effect of Niclosamide, which acts locally within the gut, is:
25. Which drug is often used as a single-dose therapy for common intestinal nematodes like Ascaris, hookworm, and Trichuris?
