Organ Interrelationships MCQ Quiz | Integrated Metabolism

Welcome to the Organ Interrelationships quiz, a vital component of the Integrated Metabolism curriculum for MBBS students. This quiz is designed to test your understanding of how different organs collaborate to maintain metabolic homeostasis in various physiological states, from fed to fasting and starvation. You will explore the intricate pathways of fuel transport, hormonal regulation, and the specific metabolic roles of the liver, muscle, adipose tissue, and brain. This assessment consists of 25 multiple-choice questions crafted to challenge your knowledge and reinforce key concepts. After submitting your answers, you will receive your score and a detailed review. You can also download a PDF of all questions with the correct answers for future revision. Good luck!

1. In the well-fed state, which organ is the primary site for converting excess glucose into triacylglycerols via de novo lipogenesis?

2. During the first 12-18 hours of fasting, which metabolic process is the primary source of blood glucose?

3. What becomes the primary fuel source for the brain during prolonged starvation (after several days)?

4. The Cori cycle describes the metabolic cooperation between which two organs through the interconversion of lactate and glucose?

5. The primary purpose of the glucose-alanine cycle is to transport:

6. Which hormone ratio is significantly elevated in the absorptive (well-fed) state?

7. In the fed state, insulin promotes the uptake of fatty acids from chylomicrons and VLDL into adipose tissue by stimulating which enzyme on the capillary endothelium?

8. Under normal physiological conditions, the brain almost exclusively uses which substrate for its energy needs?

9. What is the preferred fuel source for resting skeletal muscle in the postabsorptive state?

10. During intense, short-duration exercise (sprinting), muscle glycogen is broken down to produce ATP primarily via which pathway?

11. Besides excretion, what significant metabolic function does the kidney perform during prolonged starvation?

12. The liver plays a central role in metabolism. Which of the following processes does NOT primarily occur in the liver?

13. Ketone bodies are synthesized in the liver from which precursor molecule that is generated from fatty acid oxidation?

14. The primary targets of glucagon action to raise blood glucose are:

15. Due to their lack of mitochondria, which metabolic pathway is the sole source of ATP for red blood cells?

16. Very-low-density lipoproteins (VLDL) are synthesized and secreted by which organ to transport newly synthesized triacylglycerols to peripheral tissues?

17. During fasting, the activity of hormone-sensitive lipase (HSL) in adipose tissue is stimulated by which hormone, leading to the mobilization of fatty acids?

18. In Type 2 diabetes, a state of insulin resistance, which of the following metabolic consequences is most likely to occur in the liver?

19. After liver glycogen stores are depleted during fasting, which tissue’s protein becomes a major source of carbon skeletons for gluconeogenesis?

20. Cardiac muscle primarily relies on fatty acids for energy. This is because it:

21. Immediately after a carbohydrate-rich meal, the liver’s primary metabolic activities include:

22. The enzyme Alanine Transaminase (ALT) is crucial for the function of which inter-organ metabolic cycle?

23. The brain’s adaptation to using ketone bodies during starvation is crucial because it directly:

24. During fasting, glycerol released from adipose tissue lipolysis is transported to the liver primarily to be used as a:

25. Besides alanine, which other amino acid is a major non-toxic carrier of nitrogen from peripheral tissues to the liver?