Galactose Metabolism MCQ Quiz | Carbohydrate Metabolism

Welcome to the Galactose Metabolism Quiz for MBBS students. This quiz is designed to test your understanding of the key pathways, enzymes, and clinical conditions associated with galactose metabolism, a vital topic in carbohydrate biochemistry. You will face 25 multiple-choice questions covering the Leloir pathway, the roles of galactokinase, GALT, and UDP-galactose 4-epimerase, and the pathophysiology of classical and non-classical galactosemia. This assessment is an excellent tool for self-evaluation and revision before your professional exams. After submitting your answers, you’ll see your score and a detailed review of each question. For your convenience, you can also download a PDF copy of all questions with their correct answers for offline study. Good luck!

1. What is the primary dietary source of galactose?

2. Which enzyme is responsible for the initial phosphorylation of galactose?

3. Classical galactosemia is caused by a deficiency in which enzyme?

4. The accumulation of which metabolite is primarily responsible for the severe symptoms of classical galactosemia?

5. In the Leloir pathway, galactose-1-phosphate reacts with which molecule to form UDP-galactose?

6. Cataract formation in galactosemia is due to the accumulation of which substance in the lens?

7. Which enzyme converts galactose to galactitol?

8. A deficiency in galactokinase (GALK) leads to which condition?

9. What is the main function of UDP-galactose 4-epimerase (GALE)?

10. UDP-galactose is an essential precursor for the synthesis of which of the following?

11. In the reaction catalyzed by GALT, what are the two products formed from galactose-1-phosphate and UDP-glucose?

12. What is the recommended treatment for an infant diagnosed with classical galactosemia?

13. Which of the following is NOT a typical clinical feature of untreated classical galactosemia in neonates?

14. The conversion of UDP-galactose to UDP-glucose is an example of what type of reaction?

15. The carbon skeleton of galactose ultimately enters the glycolytic pathway as which molecule?

16. Where in the cell does the majority of galactose metabolism occur?

17. A positive test for reducing sugars in the urine but a negative glucose oxidase test suggests the presence of which sugar?

18. The enzyme lactase, which hydrolyzes lactose, is primarily found in the:

19. What is the role of UDP-glucose pyrophosphorylase in the overall context of galactose metabolism?

20. A deficiency of UDP-galactose 4-epimerase (GALE) can present as a benign, peripheral form or a severe, systemic form. The severe form resembles a deficiency of which other enzyme?

21. What is the net ATP cost to convert one molecule of galactose into glucose-6-phosphate via the Leloir pathway?

22. In which physiological state is the synthesis of lactose from UDP-galactose and glucose most active?

23. Which metal ion is often required as a cofactor for kinases like galactokinase?

24. Why are individuals with classical galactosemia particularly susceptible to E. coli sepsis in the neonatal period?

25. The complete oxidation of galactose yields approximately how many ATP molecules, similar to glucose?